Literature DB >> 6737424

Topical carbonic anhydrase inhibitors.

R D Schoenwald, M G Eller, J A Dixson, C F Barfknecht.   

Abstract

Ethoxzolamide and several derivatives (1-6) were synthesized and evaluated for carbonic anhydrase inhibition (CAI), solubility, pKa, distribution, and corneal permeability. The 6-hydroxy (5) and, particularly, the 6-chloro (6) analogues have the best combination of properties for penetrating the site of action and reducing intraocular pressure. Both 5 and 6 exhibited topical effectiveness in the normal rabbit, with 6 showing greater potency.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6737424     DOI： 10.1021/jm00372a020

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  3 in total

Review 1.  Advances in understanding the physiological role and locations of carbonic anhydrases in C3 plant cells.

Authors:  Natalia N Rudenko; Lyudmila K Ignatova; Elena M Nadeeva-Zhurikova; Tatiana P Fedorchuk; Boris N Ivanov; Maria M Borisova-Mubarakshina
Journal:  Protoplasma       Date:  2020-10-28       Impact factor: 3.356

2.  Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy.

Authors:  Andreza Ribeiro; Alejandro Sosnik; Diego A Chiappetta; Francisco Veiga; Angel Concheiro; Carmen Alvarez-Lorenzo
Journal:  J R Soc Interface       Date:  2012-04-04       Impact factor: 4.118

3.  Synthesis and anticancer activity of thiosubstituted purines.

Authors:  Alicja Kowalska; Małgorzata Latocha; Krystian Pluta
Journal:  Med Chem Res       Date:  2015-03-25       Impact factor: 1.965
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.