| Literature DB >> 6736968 |
Abstract
The acetone and methanol extracts of Gnidia kraussiana roots displayed activity against the P-388 lymphocytic leukemia. Bioactivity-directed fractionation led to the isolation of five daphnane orthoesters , all possessing potent antineoplastic activity. Four of these isolates, gnidilatin (1), gnidilatidin (2), Excoecaria toxin (3), and Pimelea factor P2 (4) have been isolated previously from plants in the Thymelaeaceae and Euphorbiaceae. The fifth compound, kraussianin (5), is a new member of the macrocyclic daphnane orthoester series of compounds.Entities:
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Year: 1984 PMID： 6736968 DOI： 10.1021/np50032a006
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050