Literature DB >> 6736163

High-performance liquid chromatography with column switching for the analysis of biogenic amine metabolites and pterins.

A Niederwieser, W Staudenmann, E Wetzel.   

Abstract

An automatic high-performance liquid chromatographic system with facilities for column switching is described which involves minimal pre-treatment of biological samples, separates complex mixtures of compounds in a short period of time and uses fluorimetric or amperometric detection. The system has been applied to the analysis of oxidized pterins in urine and reduced pterins in cerebrospinal fluid and rat brain fractions (R- and S-enantiomers of tetrahydrobiopterin resolved). The system can also be used for the analysis of most of the dopamine and serotonin metabolites in cerebrospinal fluid and brain fractions from norepinephrine to serotonin.

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Year:  1984        PMID： 6736163     DOI： 10.1016/s0021-9673(01)93579-4

Source DB:  PubMed          Journal:  J Chromatogr


  21 in total

1.  Hyperphenylalaninaemia presumably due to carbinolamine dehydratase deficiency: loading tests with pterin derivatives.

Authors:  N Blau; L Kierat; H C Curtius; M Blaskovics; T Giudici
Journal:  J Inherit Metab Dis       Date:  1992       Impact factor: 4.982

2.  Screening for tetrahydrobiopterin deficiency in newborns using dried urine on filter paper.

Authors:  N Blau; L Kierat; C W Heizmann; W Endres; T Giudici; M Wang
Journal:  J Inherit Metab Dis       Date:  1992       Impact factor: 4.982

3.  Atypical phenylketonuria with "dihydrobiopterin synthetase" deficiency: absence of phosphate-eliminating enzyme activity demonstrated in liver.

Authors:  A Niederwieser; W Leimbacher; H C Curtius; A Ponzone; F Rey; D Leupold
Journal:  Eur J Pediatr       Date:  1985-05       Impact factor: 3.183

4.  Primapterinuria: a new variant of atypical phenylketonuria.

Authors:  N Blau; H C Curtius; T Kuster; A Matasovic; G Schoedon; J L Dhondt; P Guibaud; T Giudici; M Blaskovics
Journal:  J Inherit Metab Dis       Date:  1989       Impact factor: 4.982

5.  Prenatal diagnosis of "dihydrobiopterin synthetase" deficiency, a variant form of phenylketonuria.

Authors:  A Niederwieser; H Shintaku; T Hasler; H C Curtius; H Lehmann; O Guardamagna; H Schmidt
Journal:  Eur J Pediatr       Date:  1986-08       Impact factor: 3.183

6.  Hyperphenylalaninaemia due to tetrahydrobiopterin deficiency: a report of 16 cases.

Authors:  T Coskun; I Ozalp; A Tokatli; N Blau; A Niederwieser
Journal:  J Inherit Metab Dis       Date:  1993       Impact factor: 4.982

7.  Differential diagnosis of hyperphenylalaninaemia by a combined phenylalanine-tetrahydrobiopterin loading test.

Authors:  A Ponzone; O Guardamagna; M Spada; S Ferraris; R Ponzone; L Kierat; N Blau
Journal:  Eur J Pediatr       Date:  1993-08       Impact factor: 3.183

8.  Hyperphenylalaninemia due to defects in tetrahydrobiopterin metabolism: molecular characterization of mutations in 6-pyruvoyl-tetrahydropterin synthase.

Authors:  B Thöny; W Leimbacher; N Blau; A Harvie; C W Heizmann
Journal:  Am J Hum Genet       Date:  1994-05       Impact factor: 11.025

9.  Hyperphenylalaninemia due to deficiency of 6-pyruvoyl tetrahydropterin synthase. Unusual gene dosage effect in heterozygotes.

Authors:  C R Scriver; C L Clow; P Kaplan; A Niederwieser
Journal:  Hum Genet       Date:  1987-10       Impact factor: 4.132

10.  Tetrahydrobiopterin deficiency: assay for 6-pyruvoyl-tetrahydropterin synthase activity in erythrocytes, and detection of patients and heterozygous carriers.

Authors:  H Shintaku; A Niederwieser; W Leimbacher; H C Curtius
Journal:  Eur J Pediatr       Date:  1988-01       Impact factor: 3.183
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