| Literature DB >> 6735588 |
I J Galpin, A H Wilby, G A Place, R J Beynon.
Abstract
Putative proteinase inhibitors with the general structure Z. Arg. X.Phe.H (where X = Leu, Ile or Val) were prepared by solution synthesis using semicarbazone protection for the aldehyde function. These inhibitors showed strong activity towards chymotrypsin whereas the semicarbazones and dipeptides aldehydes showed considerably reduced activity. The structural requirements for inhibition would seem to mimic those of the natural chymotrypsin inhibitor chymostatin.Entities:
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Year: 1984 PMID： 6735588 DOI： 10.1111/j.1399-3011.1984.tb02748.x
Source DB: PubMed Journal: Int J Pept Protein Res ISSN： 0367-8377