Literature DB >> 6735255

Subnormal activation of phagocytes by complement in chronic inflammatory bowel disease? Neutrophil chemotaxis to complement split product C5a.

J Elmgreen.   

Abstract

The capacity of circulating phagocytes for activation by complement was investigated in consecutive, untreated cases of chronic inflammatory bowel disease. The major complement derived chemotactic factor, C5a, served as chemoattractant in dose response studies of neutrophil chemotaxis. A similar, significantly decreased sensitivity and peak response was revealed in patients with Crohn's disease and ulcerative colitis. This subnormal function of neutrophils could be shown even in cases of complete clinical remission. Chemotactic response to casein and spontaneous motility was within the normal range showing an unaffected basic cell function of neutrophils in the patients. The study shows a dysfunction of phagocytic cells, related to potentially important phlogistic mediators, in chronic inflammatory bowel disease.

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Year:  1984        PMID： 6735255      PMCID： PMC1432611          DOI： 10.1136/gut.25.7.737

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  21 in total

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Authors:  H J Hodgson; B J Potter; D P Jewell
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Journal:  N Engl J Med       Date:  1973-02-22       Impact factor: 91.245

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Authors:  V Binder
Journal:  Scand J Gastroenterol       Date:  1970       Impact factor: 2.423

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Authors:  B J Potter; D J Brown; A Watson; D P Jewell
Journal:  Gut       Date:  1980-12       Impact factor: 23.059

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Authors:  A W Segal; G Loewi
Journal:  Lancet       Date:  1976-07-31       Impact factor: 79.321

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Authors:  I M Goldstein; D Roos; H B Kaplan; G Weissmann
Journal:  J Clin Invest       Date:  1975-11       Impact factor: 14.808

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Authors:  D E Chenoweth; T E Hugli
Journal:  Proc Natl Acad Sci U S A       Date:  1978-08       Impact factor: 11.205

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Authors:  S H Zigmond; J G Hirsch
Journal:  J Exp Med       Date:  1973-02-01       Impact factor: 14.307

10.  Formation of C3a and C5a anaphylatoxins in whole human serum after inhibition of the anaphylatoxin inactivator.

Authors:  E H Vallota; H J Müller-Eberhard
Journal:  J Exp Med       Date:  1973-05-01       Impact factor: 14.307
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  9 in total

1.  Impaired neutrophil function in intestinal lymphangiectasia.

Authors:  R P Bolton; K L Cotter; M S Losowsky
Journal:  J Clin Pathol       Date:  1986-08       Impact factor: 3.411

2.  Familial occurrence of complement dysfunction in Crohn's disease: correlation with intestinal symptoms and hypercatabolism of complement.

Authors:  J Elmgreen; H Both; V Binder
Journal:  Gut       Date:  1985-02       Impact factor: 23.059

Review 3.  Circulating neutrophils from patients with ulcerative colitis have a normal respiratory burst.

Authors:  J M Haydek; A Keshavarzian
Journal:  Inflammation       Date:  1995-12       Impact factor: 4.092

4.  'Conversion' from ulcerative colitis to Crohn's disease associated with corticosteroid treatment.

Authors:  A D Dwarakanath; J Nash; J M Rhodes
Journal:  Gut       Date:  1994-08       Impact factor: 23.059

5.  Subnormal sensitivity of neutrophils to complement split product C5a in rheumatoid arthritis: relation to complement catabolism and disease extent.

Authors:  J Elmgreen; T M Hansen
Journal:  Ann Rheum Dis       Date:  1985-08       Impact factor: 19.103

6.  Diminished neutrophil function in Crohn's disease and ulcerative colitis identified by decreased oxidative metabolism and low superoxide dismutase content.

Authors:  H W Verspaget; A S Peña; I T Weterman; C B Lamers
Journal:  Gut       Date:  1988-02       Impact factor: 23.059

7.  Serum interferon activity in inflammatory bowel disease. Arachidonic acid release and lipoxygenation activated by alpha-class interferon in human neutrophils.

Authors:  O H Nielsen; J Elmgreen; I Ahnfelt-Rønne
Journal:  Inflammation       Date:  1988-04       Impact factor: 4.092

8.  Respiratory burst of circulating polymorphonuclear leukocytes and plasma elastase levels in patients with inflammatory bowel disease in remission.

Authors:  P Gionchetti; M Campieri; C Guarnieri; A Belluzzi; C Brignola; E Bertinelli; M Ferretti; M Miglioli; L Barbara
Journal:  Dig Dis Sci       Date:  1994-03       Impact factor: 3.199

9.  Genome-wide association study of susceptibility to infection by Mycobacterium avium subspecies paratuberculosis in Holstein cattle.

Authors:  Fazli Alpay; Yalda Zare; Mamat H Kamalludin; Xixia Huang; Xianwei Shi; George E Shook; Michael T Collins; Brian W Kirkpatrick
Journal:  PLoS One       Date:  2014-12-04       Impact factor: 3.240
  9 in total

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