Perinatal brain ischaemia: impact at four years of age.

A group of 15 children for whom cerebral blood flow (CBF) had been determined during the first few hours of life were examined between the ages of 3 years 9 months and four years. Clinical neurological and psychological (Stanford-Binet) tests were carried out and in three cases a computerised tomographic examination was made. Poor articulation, dysphasia, attention deficits and low IQ were found significantly more often among the five children with a documented episode of ischaemia (CBF less than 20 ml/100g/min) in the neonatal period. By summarizing the number of abnormal findings, the difference between the groups was found to be highly significant. It is concluded that ischaemia during the first hours of life is a critical determinant for the development of congitive disorders.