Literature DB >> 6734729

Sensitization of rat forebrain neurons to serotonin by adinazolam, an antidepressant triazolobenzodiazepine.

A Turmel, C De Montigny.   

Abstract

Adinazolam , a triazolobenzodiazepine , has been reported to be an effective antidepressant treatment in major depression. In the present study, a 14-day (but not a five-day) treatment with adinazolam enhanced the responsiveness of rat hippocampal pyramidal neurons to microiontophoretically applied 5-HT but not to NE. A 14-day treatment with diazepam failed to induce sensitization to either 5-HT or NE. Acute intravenous administration of adinazolam did not modify dorsal raphe 5-HT neuron firing rate. It is proposed that the antidepressant activity of adinazolam might be mediated by a heightened 5-HT neurotransmission.

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Year:  1984        PMID： 6734729     DOI： 10.1016/0014-2999(84)90247-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

1.  Effects of antidepressants on the intraventricular conduction and the incidence of arrhythmias induced by programmed ventricular stimulation in the dog heart after myocardial infarction.

Authors:  M Nishimoto; H Hashimoto; T Ozaki; S Nagashima; M Nakashima
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-03       Impact factor: 3.000

Review 2.  Effects of long-term administration of antidepressants and neuroleptics on receptors in the central nervous system.

Authors:  G B Baker; A J Greenshaw
Journal:  Cell Mol Neurobiol       Date:  1989-03       Impact factor: 5.046

3.  Adinazolam, a new triazolobenzodiazepine, and imipramine in the treatment of major depressive disorder.

Authors:  J D Amsterdam; M Kaplan; L Potter; L Bloom; K Rickels
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

4.  N-desmethyladinazolam pharmacokinetics and behavioral effects following administration of 10-50 mg oral doses in healthy volunteers.

Authors:  J C Fleishaker; T C Smith; H Friedman; J P Phillips
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

5.  Influence of repeated administration of cimetidine on the pharmacokinetics and pharmacodynamics of adinazolam in healthy subjects.

Authors:  R Hulhoven; J P Desager; S Cox; C Harvengt
Journal:  Eur J Clin Pharmacol       Date:  1988       Impact factor: 2.953

6.  Serotonergic function during lithium augmentation of refractory depression.

Authors:  E McCance-Katz; L H Price; D S Charney; G R Heninger
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

7.  Mechanism of triazolo-benzodiazepine and benzodiazepine action in anxiety and depression: behavioral studies with concomitant in vivo CA1 hippocampal norepinephrine and serotonin release detection in the behaving animal.

Authors:  P A Broderick; O Hope; P Jeannot
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  1998-02       Impact factor: 5.067
  7 in total

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