Oral exposure to a nickel-containing dental alloy of persons with hypersensitive skin reactions to nickel.

In 10 partially dentate subjects, all with long histories of skin reactions to nickel, prosthetic treatments were performed with fixed prosthetic appliances manufactured in a dental alloy containing 66% nickel. During time periods varying from 12 to over 40 months, these subjects were controlled using a variety of dental and medical methods. Neither adverse general nor oral clinical nor histological reactions were noted during the observation.