Literature DB >> 6733363

Effects of phosphorothioate analogues of ATP, ADP and AMP on guinea-pig taenia coli and urinary bladder.

G Burnstock, N J Cusack, L A Meldrum.   

Abstract

Phosphorothioate analogues of ATP, ADP and AMP were tested on the guinea-pig taenia coli and urinary bladder. The Rp diastereoisomers of the phosphorothioate analogues, ATP-alpha-S and ADP-alpha-S were respectively 7 and 3 times more effective than the Sp diastereoisomers in causing relaxation of the taenia coli. No stereoselectivity was observed for the diastereoisomers of ATP-beta-S. In guinea-pig bladder, no stereoselectivity was observed for any of the phosphorothioate analogues. These results show that P2-purinoceptors mediating inhibitory responses in the guinea-pig taenia coli show marked stereoselectivity, while P2-purinoceptors mediating excitatory responses in the guinea-pig bladder show little stereoselectivity.

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Year:  1984        PMID： 6733363      PMCID： PMC1987028          DOI： 10.1111/j.1476-5381.1984.tb10771.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  14 in total

1.  Apamin blocks certain neurotransmitter-induced increases in potassium permeability.

Authors:  B E Banks; C Brown; G M Burgess; G Burnstock; M Claret; T M Cocks; D H Jenkinson
Journal:  Nature       Date:  1979-11-22       Impact factor: 49.962

2.  Synthesis and properties of diastereoisomers of adenosine 5'-(O-1-thiotriphosphate) and adenosine 5'-(O-2-thiotriphosphate).

Authors:  F Eckstein; R S Goody
Journal:  Biochemistry       Date:  1976-04-20       Impact factor: 3.162

3.  Comparison of the inhibitory effects on the guinea-pig taenia coli of adenine nucleotides and adenosine in the presence and absence of dipyridamole.

Authors:  D G Satchell; G Burnstock
Journal:  Eur J Pharmacol       Date:  1975 Jun-Jul       Impact factor: 4.432

4.  Effect of apamin on the electrical responses of smooth muscle to adenosine 5'-triphosphate and to non-adrenergic, non-cholinergic nerve stimulation.

Authors:  M F Shuba; I A Vladimirova
Journal:  Neuroscience       Date:  1980       Impact factor: 3.590

5.  Divalent cation-dependent stereospecificity of adenosine 5'-O-(2-thiotriphosphate) in the hexokinase and pyruvate kinase reactions. The absolute stereochemistry of the diastereoisomers of adenosine 5'-O-(2-thiotriphosphate).

Authors:  E K Jaffe; M Cohn
Journal:  J Biol Chem       Date:  1978-07-25       Impact factor: 5.157

6.  Inhibitory effects of adenine nucleotide analogs on the isolated guinea-pig taenia coli.

Authors:  D G Satchell; M H Maguire
Journal:  J Pharmacol Exp Ther       Date:  1975-12       Impact factor: 4.030

7.  Relaxation of isolated taenia coli of guinea-pig by enantiomers of 2-azido analogues of adenosine and adenine nucleotides.

Authors:  N J Cusack; M Planker
Journal:  Br J Pharmacol       Date:  1979-09       Impact factor: 8.739

8.  Comparison of the effects of ultraviolet light and purinergic nerve stimulation on the guinea-pig taenia coli.

Authors:  G Burnstock; H Wong
Journal:  Br J Pharmacol       Date:  1978-02       Impact factor: 8.739

9.  Non-cholinergic transmission by post-ganglionic motor neurones in the mammalian bladder.

Authors:  N Ambache; M A Zar
Journal:  J Physiol       Date:  1970-10       Impact factor: 5.182

10.  Atropine resistant excitation of the urinary bladder: the possibility of transmission via nerves releasing a purine nucleotide.

Authors:  G Burnstock; B Dumsday; A Smythe
Journal:  Br J Pharmacol       Date:  1972-03       Impact factor: 8.739
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  9 in total

1.  Proceedings of the British Pharmacological Society. University of Manchester, 13-15 September 1989.

Authors: 
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739

Review 2.  Extracellular ATP: effects, sources and fate.

Authors:  J L Gordon
Journal:  Biochem J       Date:  1986-01-15       Impact factor: 3.857

3.  Studies on the stereoselectivity of the P2-purinoceptor on the guinea-pig vas deferens.

Authors:  G Burnstock; N J Cusack; L A Meldrum
Journal:  Br J Pharmacol       Date:  1985-02       Impact factor: 8.739

4.  Targetable purinergic receptors P2Y12 and A2b antagonistically regulate bladder function.

Authors:  Yuan Hao; Lu Wang; Huan Chen; Warren G Hill; Simon C Robson; Mark L Zeidel; Weiqun Yu
Journal:  JCI Insight       Date:  2019-08-22

5.  Structure Activity Relationships for Derivatives of Adenosine-5'-Triphosphate as Agonists at P(2) Purinoceptors: Heterogeneity Within P(2X) and P(2Y) Subtypes.

Authors:  Geoffrey Burnstock; Bilha Fischer; Charles H V Hoyle; Michel Maillard; Airat U Ziganshin; Antonia L Brizzolara; Amy von Isakovics; José L Boyer; T Kendall Harden; Kenneth A Jacobson
Journal:  Drug Dev Res       Date:  2004-10-05       Impact factor: 4.360

6.  The activity of phosphorothioate analogues of ATP in various smooth muscle systems.

Authors:  T W Stone
Journal:  Br J Pharmacol       Date:  1985-01       Impact factor: 8.739

Review 7.  Purinergic signalling in the urinary tract in health and disease.

Authors:  Geoffrey Burnstock
Journal:  Purinergic Signal       Date:  2013-11-22       Impact factor: 3.765

8.  ADP-induced bladder contractility is mediated by P2Y12 receptor and temporally regulated by ectonucleotidases and adenosine signaling.

Authors:  Weiqun Yu; Xiaofeng Sun; Simon C Robson; Warren G Hill
Journal:  FASEB J       Date:  2014-09-10       Impact factor: 5.191

9.  Adenosine-5'-O-(2-thiodiphosphate) is a potent agonist at P2 purinoceptors mediating insulin secretion from perfused rat pancreas.

Authors:  G Bertrand; J Chapal; R Puech; M M Loubatières-Mariani
Journal:  Br J Pharmacol       Date:  1991-03       Impact factor: 8.739
  9 in total

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