Literature DB >> 6733005

Lack of effect of domperidone on gastrin release: evidence for a peripheral activity of the drug.

E Masci, R Caldara, P A Testoni, M Guslandi, M Cambielli, S Passaretti, A Tittobello.   

Abstract

The effect of intravenous administration of domperidone, a dopamine receptor antagonist with peripheral activity, on basal and submaximal pentagastrin-stimulated gastric acid secretion and gastrin release has been evaluated in healthy volunteers. No significant changes were observed in the parameters studied. The lack of effect on gastrin release appears to confirm that domperidone is unable to penetrate the blood brain barrier in appreciable amounts in adults.

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Year:  1984        PMID： 6733005      PMCID： PMC1463446          DOI： 10.1111/j.1365-2125.1984.tb02395.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  13 in total

1.  The inhibitory effect of sulpiride on pentagastrin-stimulated gastric secretion.

Authors:  S Aune; J O Stadaas
Journal:  Scand J Gastroenterol       Date:  1972       Impact factor: 2.423

2.  Gastrointestinal actions of metoclopramide. An experimental study.

Authors:  H I Jacoby; D A Brodie
Journal:  Gastroenterology       Date:  1967-04       Impact factor: 22.682

3.  Bromocriptine potentiation of gastric acid secretion in cats.

Authors:  B H Hirst; J D Reed; A Gomez-Pan; L A Labib
Journal:  Clin Endocrinol (Oxf)       Date:  1976-11       Impact factor: 3.478

4.  Effect of dopamine infusion on gastric and pancreatic secretion and on gastrin release in man.

Authors:  R Caldara; C Ferrari; M Romussi; L Bierti; S Gandini; G Curtarelli
Journal:  Gut       Date:  1978-08       Impact factor: 23.059

5.  Endocrine effects of domperidone: a peripheral dopamine blocking agent.

Authors:  G M Brown; H Verhaegan; T B Van Wimersma Greidanus; J Brugmans
Journal:  Clin Endocrinol (Oxf)       Date:  1981-09       Impact factor: 3.478

6.  Effect of four dopamine receptor antagonists on gastrin secretion in healthy subjects.

Authors:  R Caldara; C Ferrari; C Barbieri; M Romussi
Journal:  Scand J Gastroenterol       Date:  1980       Impact factor: 2.423

7.  Dopamine disorder in duodenal ulceration.

Authors:  S Szabo
Journal:  Lancet       Date:  1979-10-27       Impact factor: 79.321

8.  A role for dopamine in growth hormone regulation in the dog.

Authors:  F Casanueva; R Betti; D Cocchi; P Zanardi; T Motta; E E Müller
Journal:  Endocrinology       Date:  1981-04       Impact factor: 4.736

9.  Effect of bromocriptine administration on gastric acid and gastrin secretion in man.

Authors:  R Caldara; C Ferrari; M Romussi; A Paracchi
Journal:  J Endocrinol Invest       Date:  1979 Jan-Mar       Impact factor: 4.256

10.  Effect of gamma-aminobutyric acid on growth hormone and prolactin secretion in man: influence of pimozide and domperidone.

Authors:  F Cavagnini; G Benetti; C Invitti; G Ramella; M Pinto; M Lazza; A Dubini; A Marelli; E E Müller
Journal:  J Clin Endocrinol Metab       Date:  1980-10       Impact factor: 5.958
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  2 in total

1.  Effects of dopamine receptor antagonists on gastrin and vomiting responses to apomorphine.

Authors:  M Goiny; K Uvnäs-Moberg
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-07       Impact factor: 3.000

Review 2.  Domperidone. A review of its use in diabetic gastropathy.

Authors:  A Prakash; A J Wagstaff
Journal:  Drugs       Date:  1998-09       Impact factor: 9.546
  2 in total

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