Literature DB >> 6732796

Extracellular calcium protects isolated rat hepatocytes from injury.

M W Fariss, K Olafsdottir, D J Reed.   

Abstract

The incubation of isolated rat hepatocytes in calcium-free medium resulted in a pronounced increase in lipid peroxidation, mitochondrial and cytoplasmic glutathione depletion, glutathione disulfide formation and efflux of reduced glutathione as compared with hepatocytes incubated in calcium containing medium. These data suggest that extracellular calcium ions serve a protective role in isolated rat hepatocytes against cell injury.

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Year:  1984        PMID： 6732796     DOI： 10.1016/0006-291x(84)90693-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  Late steady increase in cytosolic Ca2+ preceding hypoxic injury in hepatocytes.

Authors:  M Brecht; C Brecht; H De Groot
Journal:  Biochem J       Date:  1992-04-15       Impact factor: 3.857

2.  Altered calcium homeostasis in irreversibly injured P388D1 macrophages.

Authors:  G F Gleva; L A Goodglick; A B Kane
Journal:  Am J Pathol       Date:  1990-07       Impact factor: 4.307

3.  Searching for mechanisms of N-methyl-D-aspartate-induced glutathione efflux in organotypic hippocampal cultures.

Authors:  Camilla Wallin; Abdul-Karim Abbas; Mattias Tranberg; Stephen G Weber; Holger Wigström; Mats Sandberg
Journal:  Neurochem Res       Date:  2003-02       Impact factor: 3.996

4.  [The electrolyte composition of liver preservation solutions for hepatocytes in a model of in vitro preservation and reoxygenation].

Authors:  K Klöppel; J Gerlach; P Neuhaus
Journal:  Langenbecks Arch Chir       Date:  1994

5.  Kinetics of cell death induced in 10T1/2 cells by methyl methanesulfonate and the effects of extracellular calcium on cell death.

Authors:  G J Smith; J W Grisham; M M Fatteh
Journal:  Am J Pathol       Date:  1986-03       Impact factor: 4.307

6.  Pancreatic B cells possess defense mechanisms against cell-specific toxicity.

Authors:  D Pipeleers; M Van de Winkel
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

Review 7.  Extracellular calcium effects on cell viability and thiol homeostasis.

Authors:  D J Reed; G A Pascoe; C E Thomas
Journal:  Environ Health Perspect       Date:  1990-03       Impact factor: 9.031

Review 8.  Mechanisms of cell injury by activated oxygen species.

Authors:  J L Farber
Journal:  Environ Health Perspect       Date:  1994-12       Impact factor: 9.031
  8 in total

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