Literature DB >> 6732769

Peroxisomal fatty acid oxidation is selectively inhibited by phenothiazines in isolated hepatocytes.

F Leighton, R Pérsico, C Necochea.   

Abstract

The production of hydrogen peroxide by isolated hepatocytes in response to lauric, palmitic and oleic acids, a measurement of peroxisomal fatty acid oxidation, is inhibited by phenothiazines under conditions in which ketone body production, a measurement of mitochondrial fatty acid oxidation, does not reveal inhibition of mitochondrial activity. This novel finding provides a pharmacological tool for the study of peroxisomal function in whole cells. The mechanism of this effect of phenothiazines, detected in hepatocytes from rats treated with a peroxisome proliferation inducing drug, is not yet known.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6732769     DOI： 10.1016/0006-291x(84)91283-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Peroxisomal oxidation of erucic acid suppresses mitochondrial fatty acid oxidation by stimulating malonyl-CoA formation in the rat liver.

Authors:  Xiaocui Chen; Lin Shang; Senwen Deng; Ping Li; Kai Chen; Ting Gao; Xiao Zhang; Zhilan Chen; Jia Zeng
Journal:  J Biol Chem       Date:  2020-06-03       Impact factor: 5.157

2.  Comparison of the activities of some peroxisomal and extraperoxisomal lipid-metabolizing enzymes in liver and extrahepatic tissues of the rat.

Authors:  P Van Veldhoven; G P Mannaerts
Journal:  Biochem J       Date:  1985-05-01       Impact factor: 3.857

Review 3.  On the molecular etiology of decreased arachidonic (20:4n-6), docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n-3) acids in Zellweger syndrome and other peroxisomal disorders.

Authors:  J P Infante; V A Huszagh
Journal:  Mol Cell Biochem       Date:  1997-03       Impact factor: 3.396

4.  Chlorpromazine and carnitine-dependency of rat liver peroxisomal beta-oxidation of long-chain fatty acids.

Authors:  J Vamecq
Journal:  Biochem J       Date:  1987-02-01       Impact factor: 3.857

5.  Involvement of carnitine acyltransferases in peroxisomal fatty acid metabolism by the yeast Pichia guilliermondii.

Authors:  Y Pagot; J M Belin
Journal:  Appl Environ Microbiol       Date:  1996-10       Impact factor: 4.792

6.  Peroxisomal fatty acid oxidation and inhibitors of the mitochondrial carnitine palmitoyltransferase I in isolated rat hepatocytes.

Authors:  C Skorin; C Necochea; V Johow; U Soto; A M Grau; J Bremer; F Leighton
Journal:  Biochem J       Date:  1992-01-15       Impact factor: 3.857
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.