Verrucous-squamous carcinomas of the oral cavity. A clinicopathologic study of 104 cases.

One hundred four patients had verrucous carcinomas of the oral cavity. Our study documents, for the first time, the coexistence of foci of less-differentiated squamous carcinoma within verrucous lesions of the oral cavity (20%). We confirm previous observations that verrucous lesions tend to recur in the form of less-differentiated carcinomas. Finally, we demonstrate that surgery is indeed the treatment of choice for verrucous carcinomas of the oral cavity, although irradiation can be used to treat selected patients.