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Literature DB >> 673020

Suppression of 3H-acetylcholine release from primary nerve cell cultures by tetanus and botulinum-A toxin.

Abstract

Primary nerve cell cultures derived from embryonic rat central nervous system form [3H]ACh from exogenous [3H]Ch, and release it upon potassium depolarization. Pretreatment of the cultures with botulinum-A toxin or tetanus toxin diminishes the cellular accumulation of [3H]ACh. Poisoning the cultures during the period of [3H]Ch uptake fails to lower [H]ACh formation. Dependent on dosage, both toxins suppress the release of [3H]ACh upon potassium depolarization. Heat-denaturated toxins as well as tetanus toxin preincubated with tetanus antitoxin were without effect.

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Year: 1978 PMID： 673020 DOI： 10.1007/BF00508058

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

34 in total

1. ACTIVITY OF TYPE A BOTULINAL TOXIN AND HEMAGGLUTININ EXPOSED TO PROTEOLYTIC ENZYME.

Authors: E A Meyer; C Lamanna
Journal: J Bacteriol Date: 1959-08 Impact factor: 3.490

2. Gangliosides in nervous tissue cultures and binding of 125I-labelled tetanus toxin, a neuronal marker.

Authors: W Dimpfel; R T Huang; E Habermann
Journal: J Neurochem Date: 1977-08 Impact factor: 5.372

3. Mouse spinal cord in cell culture. IV. Modulation of inhibitory synaptic function.

Authors: P G Nelson; B R Ransom; M Henkart; P N Bullock
Journal: J Neurophysiol Date: 1977-09 Impact factor: 2.714

4. Neurons from fetal rat brain in a new cell culture system: a multidisciplinary analysis.

Authors: E W Godfrey; P G Nelson; B K Schrier; A C Breuer; B R Ransom
Journal: Brain Res Date: 1975-06-06 Impact factor: 3.252

5. Inhibition by botulinum toxin of depolarization-evoked release of (14C)acetylcholine from synaptosomes in vitro.

Authors: S Wonnacott; R M Marchbanks
Journal: Biochem J Date: 1976-06-15 Impact factor: 3.857

6. The labelling of motor end-plates in skeletal muscle of mice with 125I tetanus toxin.

Authors: A Wernig; H Stöver; D Tonge
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1977-05 Impact factor: 3.000

7. The effects of tetanus toxin on neuromuscular transmission and on the morphology of motor end-plates in slow and fast skeletal muscle of the mouse.

Authors: L W Duchen; D A Tonge
Journal: J Physiol Date: 1973-01 Impact factor: 5.182

8. Tetanus toxin inhibits amino acid release from nerve endings in vitro.

Authors: R H Osborne; H F Bradford
Journal: Nat New Biol Date: 1973-08-01

9. Tetanus toxin and the synaptic release of GABA.

Authors: D R Curtis; D Felix; C J Game; R M McCulloch
Journal: Brain Res Date: 1973-03-15 Impact factor: 3.252

10. Changes in the electron microscopic structure of slow and fast skeletal muscle fibres of the mouse after the local injection of botulinum toxin.

Authors: L W Duchen
Journal: J Neurol Sci Date: 1971-09 Impact factor: 3.181

15 in total

1. Effects of ion channel toxins and specific neurotoxins on the cyclic nucleotide content of cerebellar slices, primary brain cultures and neural cell lines.

Authors: G Ahnert; H Glossmann; E Habermann
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1979-06 Impact factor: 3.000

Review 2. Tetanus toxin.

Authors: B Bizzini
Journal: Microbiol Rev Date: 1979-06

3. Tetanus toxin and botulinum A toxin inhibit release and uptake of various transmitters, as studied with particulate preparations from rat brain and spinal cord.

Authors: H Bigalke; I Heller; B Bizzini; E Habermann
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1981-06 Impact factor: 3.000

Review 4. Clostridium botulinum neurotoxin.

Authors: H Sugiyama
Journal: Microbiol Rev Date: 1980-09

5. Tetanus toxin blocks the neuromuscular transmission in vitro like botulinum A toxin.

Authors: E Habermann; F Dreyer; H Bigalke
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1980-02 Impact factor: 3.000

6. Inhibition of synaptosomal choline uptake by tetanus and botulinum A toxin. Partial dissociation of fixation and effect of tetanus toxin.

Authors: E Habermann; H Bigalke; I Heller
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1981-04 Impact factor: 3.000