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Literature DB >> 672957

Where do general anaesthetics act?

Abstract

General anaesthetics were found to have no effect on lipid bilayer structures when studied using X-ray and neutron diffraction. Combined gaseous and aqueous phase solubility data suggested that the primary site of action of general anaesthetics has both polar and nonpolar characteristics, and probably involves protein.

Entities: Chemical

Mesh：

Substances：

Year: 1978 PMID： 672957 DOI： 10.1038/274339a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

44 in total

1. Effect of inhalation anesthetics on swimming activity of artemia salina.

Authors: M Takasaki; T Tatara; Y Suezaki; K Shirahama; H Kamaya; I Ueda; T Totoki
Journal: J Anesth Date: 1991-07 Impact factor: 2.078

2. Truncated human serum albumin retains general anaesthetic binding activity.

Authors: Renyu Liu; Jinsheng Yang; Chung-Eun Ha; Nadhipuram V Bhagavan; Roderic G Eckenhoff
Journal: Biochem J Date: 2005-05-15 Impact factor: 3.857

Review 3. Neuronal activity: from in vitro preparation to behaving animals.

Authors: François Windels
Journal: Mol Neurobiol Date: 2006-08 Impact factor: 5.590

4. Breaking the Meyer-Overton rule: predicted effects of varying stiffness and interfacial activity on the intrinsic potency of anesthetics.

Authors: R S Cantor
Journal: Biophys J Date: 2001-05 Impact factor: 4.033

5. Contradicting a unitary theory of general anesthetic action: a history of three compounds from 1901 to 2001.

Authors: Matthew D Krasowski
Journal: Bull Anesth Hist Date: 2003-07

6. Anesthetic inhibition of firefly luciferase, a protein model for general anesthesia, does not exhibit pressure reversal.

Authors: G W Moss; W R Lieb; N P Franks
Journal: Biophys J Date: 1991-12 Impact factor: 4.033

Where do general anaesthetics act?

1. Effect of inhalation anesthetics on swimming activity of artemia salina.

2. Truncated human serum albumin retains general anaesthetic binding activity.

Review 3. Neuronal activity: from in vitro preparation to behaving animals.

4. Breaking the Meyer-Overton rule: predicted effects of varying stiffness and interfacial activity on the intrinsic potency of anesthetics.

5. Contradicting a unitary theory of general anesthetic action: a history of three compounds from 1901 to 2001.

6. Anesthetic inhibition of firefly luciferase, a protein model for general anesthesia, does not exhibit pressure reversal.

7. Structural basis for the inhibition of firefly luciferase by a general anesthetic.

Review 8. A hypothesis about the endogenous analogue of general anesthesia.

9. Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties.

Review 10. A new look at lipid-membrane structure in relation to drug research.