Literature DB >> 6729040

The relative biological effectiveness in V79 Chinese hamster cells of the neutron capture reactions in boron and nitrogen.

D Gabel, R G Fairchild, B Larsson, H G Börner.   

Abstract

V79 Chinese hamster cells were irradiated in the presence of different amounts of boric acid with thermal neutrons at the Medical Research Reactor at Brookhaven National Laboratory. From the linear dose-survival curves observed, a D0 value of 66 rad for the 10B(n, alpha) 7Li neutron capture reaction was obtained. No dependence of this value on the concentration of boric acid was found. Comparing this value to the D0 value of 150 rad obtained with 250 kVp X rays between 10 and 0.01% survival, an extrapolated RBE value of 2.3 was calculated. By irradiation of the same line of cells with cold neutrons at the Institut Laue - Langevin , a D0 value for the 14N(n,p)14C reaction of 77 rad was obtained, with a corresponding RBE value of 1.9. Comparison is made with previously published RBE values for the 10B(n, alpha) 7Li reaction.

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Year:  1984        PMID： 6729040

Source DB:  PubMed          Journal:  Radiat Res        ISSN： 0033-7587            Impact factor:   2.841


  9 in total

1.  Boron neutron capture therapy of intracerebral rat gliosarcomas.

Authors:  D D Joel; R G Fairchild; J A Laissue; S K Saraf; J A Kalef-Ezra; D N Slatkin
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

2.  Boron neutron capture therapy (BNCT) for the treatment of liver metastases: biodistribution studies of boron compounds in an experimental model.

Authors:  Marcela A Garabalino; Andrea Monti Hughes; Ana J Molinari; Elisa M Heber; Emiliano C C Pozzi; Jorge E Cardoso; Lucas L Colombo; Susana Nievas; David W Nigg; Romina F Aromando; Maria E Itoiz; Verónica A Trivillin; Amanda E Schwint
Journal:  Radiat Environ Biophys       Date:  2010-12-05       Impact factor: 1.925

3.  Enhanced survival of glioma bearing rats following boron neutron capture therapy with blood-brain barrier disruption and intracarotid injection of boronophenylalanine.

Authors:  W Yang; R F Barth; J H Rotaru; M L Moeschberger; D D Joel; M M Nawrocky; J H Goodman
Journal:  J Neurooncol       Date:  1997-05       Impact factor: 4.130

4.  Central nervous system radiation syndrome in mice from preferential 10B(n, alpha)7Li irradiation of brain vasculature.

Authors:  D N Slatkin; R D Stoner; K M Rosander; J A Kalef-Ezra; J A Laissue
Journal:  Proc Natl Acad Sci U S A       Date:  1988-06       Impact factor: 11.205

5.  Biodistribution of sodium borocaptate (BSH) for boron neutron capture therapy (BNCT) in an oral cancer model.

Authors:  Marcela A Garabalino; Elisa M Heber; Andrea Monti Hughes; Sara J González; Ana J Molinari; Emiliano C C Pozzi; Susana Nievas; Maria E Itoiz; Romina F Aromando; David W Nigg; William Bauer; Verónica A Trivillin; Amanda E Schwint
Journal:  Radiat Environ Biophys       Date:  2013-04-17       Impact factor: 1.925

6.  Estimation of relative biological effectiveness for boron neutron capture therapy using the PHITS code coupled with a microdosimetric kinetic model.

Authors:  Hironori Horiguchi; Tatsuhiko Sato; Hiroaki Kumada; Tetsuya Yamamoto; Takeji Sakae
Journal:  J Radiat Res       Date:  2014-11-26       Impact factor: 2.724

7.  Biodistribution of boron concentration on melanoma-bearing hamsters after administration of p-, m-, o-boronophenylalanine.

Authors:  J Hiratsuka; K Yoshino; H Kondoh; Y Imajo; Y Mishima
Journal:  Jpn J Cancer Res       Date:  2000-04

8.  Pharmacokinetics in melanoma-bearing mice of 5-dihydroxyboryl-6-propyl-2-thiouracil (BPTU), a candidate compound for boron neutron capture therapy.

Authors:  R Verrijk; I J Smolders; R Huiskamp; P R Gavin; K H Philipp; A C Begg
Journal:  Br J Cancer       Date:  1994-04       Impact factor: 7.640

9.  Thermal Neutron Relative Biological Effectiveness Factors for Boron Neutron Capture Therapy from In Vitro Irradiations.

Authors:  María Pedrosa-Rivera; Javier Praena; Ignacio Porras; Manuel P Sabariego; Ulli Köster; Michael Haertlein; V Trevor Forsyth; José C Ramírez; Clara Jover; Daniel Jimena; Juan L Osorio; Patricia Álvarez; Carmen Ruiz-Ruiz; María J Ruiz-Magaña
Journal:  Cells       Date:  2020-09-23       Impact factor: 6.600
  9 in total

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