Literature DB >> 6728676

In situ activation of bis-dialkylaminophosphines--a new method for synthesizing deoxyoligonucleotides on polymer supports.

A D Barone, J Y Tang, M H Caruthers.   

Abstract

Deoxynucleoside phosphoramidites can be prepared in good yield from deoxynucleosides, bis- dialkylaminophosphines , and the corresponding dialkylamine hydrotetrazolide or tetrazole as catalysts. These phosphoramidites generated in situ lead to the direct synthesis of deoxyoligonucleotides on polymer supports.

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Year:  1984        PMID： 6728676      PMCID： PMC318815          DOI： 10.1093/nar/12.10.4051

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  2 in total

1.  Restriction and modification of a self-complementary octanucleotide containing the EcoRI substrate.

Authors:  P H Greene; M S Poonian; A L Nussbaum; L Tobias; D E Garfin; H W Boyer; H M Goodman
Journal:  J Mol Biol       Date:  1975-12-05       Impact factor: 5.469

2.  Synthesis of oligodeoxyribonucleotides on silica gel support.

Authors:  F Chow; T Kempe; G Palm
Journal:  Nucleic Acids Res       Date:  1981-06-25       Impact factor: 16.971
  2 in total
  42 in total

1.  Association of 2'-5' oligoribonucleotides.

Authors:  R Kierzek; L He; D H Turner
Journal:  Nucleic Acids Res       Date:  1992-04-11       Impact factor: 16.971

2.  Chemical synthesis of branched RNA.

Authors:  R Kierzek; D W Kopp; M Edmonds; M H Caruthers
Journal:  Nucleic Acids Res       Date:  1986-06-25       Impact factor: 16.971

3.  Selective O-phosphitilation with nucleoside phosphoramidite reagents.

Authors:  S M Gryaznov; R L Letsinger
Journal:  Nucleic Acids Res       Date:  1992-04-25       Impact factor: 16.971

4.  The synthesis and stability of oligodeoxyribonucleotides containing the deoxyadenosine mimic 1-(2'-deoxy-beta-D-ribofuranosyl)imidazole-4-carboxamide.

Authors:  W T Johnson; P Zhang; D E Bergstrom
Journal:  Nucleic Acids Res       Date:  1997-02-01       Impact factor: 16.971

5.  Modulation of oligonucleotide duplex and triplex stability via hydrophobic interactions.

Authors:  S M Gryaznov; D H Lloyd
Journal:  Nucleic Acids Res       Date:  1993-12-25       Impact factor: 16.971

6.  The synthesis of 2-pyrimidinone nucleosides and their incorporation into oligodeoxynucleotides.

Authors:  B Gildea; L W McLaughlin
Journal:  Nucleic Acids Res       Date:  1989-03-25       Impact factor: 16.971

7.  Application of 2-cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite for in situ preparation of deoxyribonucleoside phosphoramidites and their use in polymer-supported synthesis of oligodeoxyribonucleotides.

Authors:  J Nielsen; M Taagaard; J E Marugg; J H van Boom; O Dahl
Journal:  Nucleic Acids Res       Date:  1986-09-25       Impact factor: 16.971

8.  Chemical synthesis and biological characterization of phosphorothioate analogs of 2', 5'-3'-deoxyadenylate trimer.

Authors:  R W Sobol; R Charubala; W Pfleiderer; R J Suhadolnik
Journal:  Nucleic Acids Res       Date:  1993-05-25       Impact factor: 16.971

9.  Synthesis and structure assignments of amide protected nucleosides and their use as phosphoramidites in deoxyoligonucleotide synthesis.

Authors:  M Mag; J W Engels
Journal:  Nucleic Acids Res       Date:  1988-04-25       Impact factor: 16.971

10.  Solid phase synthesis of oligoribonucleotides using o-nitrobenzyl protection of 2'-hydroxyl via a phosphite triester approach.

Authors:  T Tanaka; S Tamatsukuri; M Ikehara
Journal:  Nucleic Acids Res       Date:  1986-08-11       Impact factor: 16.971
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