Literature DB >> 6728638

A new and improved gas chromatographic method for the determination of fluoride in plasma and faeces.

J H Glerum, A Van Dijk, S W Klein.   

Abstract

A method is described that extracts fluoride selectively as trimethylfluorosilane using carbon tetrachloride and trimethylchlorosilane . Drawbacks of other methods as well as advantages of the proposed method are discussed. The method is directly applicable to plasma and faeces samples, has a short gas chromatographic run time due to the use of a backflush technique and is suitable for automation. Its lowest quantifiable limit for plasma and faeces is 10 micrograms/l and 1 microgram/g fluoride respectively, using 1.0 ml or 1.0 g samples. Preliminary pharmacokinetic parameters of fluoride obtained in two subjects are reported.

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Year:  1984        PMID： 6728638     DOI： 10.1007/BF01953958

Source DB:  PubMed          Journal:  Pharm Weekbl Sci        ISSN： 0167-6555


  7 in total

1.  Effect of sodium fluoride on calcium metabolism of human beings.

Authors:  C RICH; J ENSINCK
Journal:  Nature       Date:  1961-07-08       Impact factor: 49.962

2.  Linear pharmacokinetic equations allowing direct calculation of many needed pharmacokinetic parameters from the coefficients and exponents of polyexponential equations which have been fitted to the data.

Authors:  J G Wagner
Journal:  J Pharmacokinet Biopharm       Date:  1976-10

3.  The determination of fluoride in biological materials by means of gas chromatography.

Authors:  J A Fresen; F H Cox; M J Witter
Journal:  Pharm Weekbl       Date:  1968-08-16

4.  Serum fluoride analysis with the fluoride electrode.

Authors:  B W Fry; D R Taves
Journal:  J Lab Clin Med       Date:  1970-06

5.  Symbols in pharmacokinetics.

Authors:  M Rowland; G Tucker
Journal:  J Pharmacokinet Biopharm       Date:  1980-10

6.  Serum ionic fluoride: normal range and relationship to age and sex.

Authors:  H Husdan; R Vogl; D Oreopoulos; C Gryfe; A Rapoport
Journal:  Clin Chem       Date:  1976-11       Impact factor: 8.327

7.  Fluoride bioavailability after intravenous and oral administration: importance of renal clearance and urine flow.

Authors:  J Ekstrand; M Ehrnebo; L O Boréus
Journal:  Clin Pharmacol Ther       Date:  1978-03       Impact factor: 6.875
  7 in total
  2 in total

1.  A general system for the automation of a backflush equipped gas chromatograph and its application in the determination of fluoride in plasma and faeces.

Authors:  J H Glerum; A Van Dijk; S W Klein; W C Nuyen
Journal:  Pharm Weekbl Sci       Date:  1985-06-21

2.  Cytogenetic effects on lymphocytes in osteoporotic patients on long-term fluoride therapy.

Authors:  P van Asten; F Darroudi; A T Natarajan; I J Terpstra; S A Duursma
Journal:  Pharm World Sci       Date:  1998-10
  2 in total

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