Literature DB >> 6726625

pKa determination of verapamil by liquid-liquid partition.

J Hasegawa, T Fujita, Y Hayashi, K Iwamoto, J Watanabe.   

Abstract

The pKa of verapamil was determined by measuring the partition coefficient of verapamil between n-heptane and aqueous buffer solution at various pH values. The magnitude of the effects of ionic strength or temperature on the pKa of verapamil was in agreement with those reported previously. The estimated pKa of verapamil in human plasma was 8.75. The pKa of 2,4,6-trimethylpyridine measured by means of the present partition method was in good agreement with that determined by UV spectrophotometry.

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Year:  1984        PMID： 6726625     DOI： 10.1002/jps.2600730405

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  11 in total

1.  Silicone adhesive matrix of verapamil hydrochloride to provide pH-independent sustained release.

Authors:  Gaurav Tolia; S Kevin Li
Journal:  AAPS PharmSciTech       Date:  2014-02       Impact factor: 3.246

2.  Interaction of verapamil with lipid membranes and P-glycoprotein: connecting thermodynamics and membrane structure with functional activity.

Authors:  M Meier; X Li Blatter; A Seelig; J Seelig
Journal:  Biophys J       Date:  2006-07-28       Impact factor: 4.033

3.  Action of tertiary phenylalkylamines on cardiac transient outward current from outside the cell membrane.

Authors:  J W Wegener; H Nawrath
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996-12       Impact factor: 3.000

4.  Saquinavir inhibits the malaria parasite's chloroquine resistance transporter.

Authors:  Rowena E Martin; Alice S Butterworth; Donald L Gardiner; Kiaran Kirk; James S McCarthy; Tina S Skinner-Adams
Journal:  Antimicrob Agents Chemother       Date:  2012-02-21       Impact factor: 5.191

5.  Sensitive and valid assay for reliable evaluation of drug interactions mediated by human organic anion transporter 1 and 3 using 5-carboxyfluorescein.

Authors:  Kyeong-Ryoon Lee; Ji-Eun Chang; Yoon-Jee Chae
Journal:  Anal Sci       Date:  2022-07-27       Impact factor: 1.967

6.  Column-switching high-performance liquid chromatography for on-line simultaneous determination and resolution of enantiomers of verapamil and its metabolites.

Authors:  Y Oda; N Asakawa; T Kajima; Y Yoshida; T Sato
Journal:  Pharm Res       Date:  1991-08       Impact factor: 4.200

7.  Cardiovascular responses to verapamil and nifedipine in hypoventilated and hyperventilated rats.

Authors:  F I Achike; S Dai
Journal:  Br J Pharmacol       Date:  1990-05       Impact factor: 8.739

8.  Coronary vasodilator and cardiac effects of NKY-722, a novel hydrophilic 1,4-dihydropyridine derivative, in the blood-perfused dog heart.

Authors:  J Imagawa; K Satoh; N Taira
Journal:  Cardiovasc Drugs Ther       Date:  1989-03       Impact factor: 3.727

9.  Development of Methods for the Determination of pKa Values.

Authors:  Jetse Reijenga; Arno van Hoof; Antonie van Loon; Bram Teunissen
Journal:  Anal Chem Insights       Date:  2013-08-08

10.  Multiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sites.

Authors:  Sebastiano Bellanca; Robert L Summers; Max Meyrath; Anurag Dave; Megan N Nash; Martin Dittmer; Cecilia P Sanchez; Wilfred D Stein; Rowena E Martin; Michael Lanzer
Journal:  J Biol Chem       Date:  2014-11-06       Impact factor: 5.157
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