Literature DB >> 6723986

Inhibition of synaptosomal 5-[3H]hydroxytryptamine uptake by endogenous factor(s) in human blood.

I Angel, S M Paul.   

Abstract

The inhibition of 5-[3H]hydroxytryptamine uptake into rat forebrain synaptosomes by human plasma extracts was studied. Highly potent, small (Mr less than 10 000), and heat stable factor(s) were found to inhibit 5-[3H]hydroxytryptamine uptake specifically, reversibly and in a non-competitive manner. The possible role of these factor(s) as endogenous modulators of serotonergic activity is discussed.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6723986     DOI： 10.1016/0014-5793(84)80504-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  4 in total

1.  Reduced Bmax of [3H]-imipramine binding to platelets of depressed patients free of previous medication with 5HT uptake inhibitors.

Authors:  M F Poirier; C Benkelfat; H Loo; D Sechter; E Zarifian; A M Galzin; S Z Langer
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

Review 2.  Studies on the serotonin transporter in platelets.

Authors:  S Z Langer; A M Galzin
Journal:  Experientia       Date:  1988-02-15

3.  Alteration of 5-HT uptake by plasma fractions in the premenstrual syndrome.

Authors:  C R Ashby; L A Carr; C L Cook; M M Steptoe; D D Franks
Journal:  J Neural Transm Gen Sect       Date:  1990

4.  2-Nitroimipramine: a photoaffinity probe for the serotonin uptake/tricyclic binding site complex.

Authors:  L P Wennogle; R A Ashton; D I Schuster; R B Murphy; L R Meyerson
Journal:  EMBO J       Date:  1985-04       Impact factor: 11.598
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.