Literature DB >> 6723926

Model systems demonstrating the volatile mutagenicity and carcinogenicity of sodium nitrite in rats.

I A Macdonald, J A Mader, B G Rao, D A Malatjalian.   

Abstract

Volatile mutagens derived from sodium nitrite buffered at various pH values or in the presence of human feces were detected using Ames Salmonella tester strain TA 1535 on petrie plates inverted over samples. Volatile mutagenicity increased as the pH decreased and was primarily a function of the nitrous acid produced from sodium nitrite and hydrogen ions. Sodium nitrite administered intracecally to 3 Wistar rats through surgically implanted cannula caused tumors (fibrosarcoma: 1/3 and squamous cell, 2/3). The possible role of nitrite-derived mutagens in GI cancer is discussed.

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Year:  1984        PMID： 6723926     DOI： 10.1007/BF01982327

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

Authors:  J McCann; E Choi; E Yamasaki; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1975-12       Impact factor: 11.205

2.  An improved bacterial test system for the detection and classification of mutagens and carcinogens.

Authors:  B N Ames; F D Lee; W E Durston
Journal:  Proc Natl Acad Sci U S A       Date:  1973-03       Impact factor: 11.205

3.  Carcinoma of the gastric stump.

Authors:  L Morgenstern; T Yamakawa; D Seltzer
Journal:  Am J Surg       Date:  1973-01       Impact factor: 2.565

4.  Are nitrite and N-nitroso compounds in gastric juice risk factors for carcinoma in the operated stomach?

Authors:  P Schlag; R Böckler; H Ulrich; M Peter; P Merkle; C Herfarth
Journal:  Lancet       Date:  1980-04-05       Impact factor: 79.321

5.  Volatile nitrosamines in normal human faeces.

Authors:  T Wang; T Kakizoe; P Dion; R Furrer; A J Varghese; W R Bruce
Journal:  Nature       Date:  1978-11-16       Impact factor: 49.962

6.  Formation of ether-soluble Griess reagent-positive material from human feces and sodium nitrite.

Authors:  B G Rao; D M Hutchison; I A MacDonald
Journal:  Environ Res       Date:  1980-12       Impact factor: 6.498

7.  General structure of "fecapentaenes"--the mutagenic substances in human faeces: a preliminary report.

Authors:  W R Bruce; J Baptista; T Che; R Furrer; J S Gingerich; I Gupta; J J Krepinsky; A A Grey; P Yates
Journal:  Naturwissenschaften       Date:  1982-11

8.  Nitrite and nitrate are formed by endogenous synthesis in the human intestine.

Authors:  S R Tannenbaum; D Fett; V R Young; P D Land; W R Bruce
Journal:  Science       Date:  1978-06-30       Impact factor: 47.728

9.  Nitrite-induced volatile fecal mutagens: some preliminary studies.

Authors:  I A MacDonald; B G Rao
Journal:  Cancer       Date:  1982-04-01       Impact factor: 6.860

10.  Nitrite-induced volatile mutagens from normal human feces.

Authors:  B G Rao; I A MacDonald; D M Hutchison
Journal:  Cancer       Date:  1981-03-01       Impact factor: 6.860
  10 in total

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