Literature DB >> 6723784

Role of serotonin in the analgesic activity of calcitonin.

G Clementi, A Prato, G Conforto, U Scapagnini.   

Abstract

The acute effects of peripherally administered methysergide or phentolamine on the analgesic activity of salmon calcitonin (sCT) injected into the lateral ventricle were investigated in male rats. Methysergide, but not phentolamine, significantly (P less than 0.05) antagonized the analgesic activity of sCT at 60 and 120 min after the administration of the peptide. The results obtained suggest that the analgesic activity of sCT may involve central serotonergic system(s), while the central noradrenergic system does not seem to be needed for this activity.

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Year:  1984        PMID： 6723784     DOI： 10.1016/0014-2999(84)90298-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

1.  Mechanisms for ovariectomy-induced hyperalgesia and its relief by calcitonin: participation of 5-HT1A-like receptor on C-afferent terminals in substantia gelatinosa of the rat spinal cord.

Authors:  A Ito; E Kumamoto; M Takeda; K Shibata; H Sagai; M Yoshimura
Journal:  J Neurosci       Date:  2000-08-15       Impact factor: 6.167

Review 2.  Salmon calcitonin: a review of current and future therapeutic indications.

Authors:  C H Chesnut; M Azria; S Silverman; M Engelhardt; M Olson; L Mindeholm
Journal:  Osteoporos Int       Date:  2007-12-11       Impact factor: 4.507

3.  Enterochromaffin cells in the stomach of the rat after prolonged administration of cortisol and both cortisol and salmon calcitonin.

Authors:  G Orlicz-Szczesna; M Jabtoński; M Gorzelak
Journal:  J Endocrinol Invest       Date:  1999-05       Impact factor: 4.256

4.  Anti-nociceptive effects of elcatonin injection for postmenopausal women with back pain: a randomized controlled trial.

Authors:  Shota Ikegami; Mikio Kamimura; Shigeharu Uchiyama; Hiroyuki Nakagawa; Hiroyuki Hashidate; Kenji Takahara; Jun Takahashi; Hiroyuki Kato
Journal:  Open Orthop J       Date:  2010-03-04

Review 5.  Calcitonin and its antinociceptive activity: animal and human investigations 1975-1992.

Authors:  P C Braga
Journal:  Agents Actions       Date:  1994-05

6.  [Calcitonin.].

Authors:  C Maier
Journal:  Schmerz       Date:  1990-03       Impact factor: 1.107

7.  Effects of Salmon Calcitonin on the Concentrations of Monoamines in Periaqueductal Gray in Formalin Test

Authors:  Kaveh Rahimi; Javad Sajedianfard; Ali Akbar Owji
Journal:  Balkan Med J       Date:  2019-06-20       Impact factor: 2.021

Review 8.  Beyond CGRP: The calcitonin peptide family as targets for migraine and pain.

Authors:  Tayla A Rees; Erica R Hendrikse; Debbie L Hay; Christopher S Walker
Journal:  Br J Pharmacol       Date:  2021-07-27       Impact factor: 9.473
  8 in total

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