Literature DB >> 6723489

The influence of asphyxia on phenobarbital dosing requirements in neonates.

P Gal, J Toback, N V Erkan, H R Boer.   

Abstract

phenobarbital dosing requirements and plasma clearance were examined for asphyxiated and nonasphyxiated neonates. The gestational age, postnatal age, duration of phenobarbital therapy and plasma phenobarbital concentrations were similar for the two groups. The plasma phenobarbital clearance was 4.1 +/- 1.0 (SD) and 8.7 +/- 3.9 (SD) ml/kg/h for asphyxiated and nonasphyxiated neonates, respectively. Asphyxiated neonates only require about half the maintenance dose of nonasphyxiated neonates to achieve similar plasma concentrations.

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Year:  1984        PMID： 6723489     DOI： 10.1159/000457157

Source DB:  PubMed          Journal:  Dev Pharmacol Ther        ISSN： 0379-8305


  11 in total

Review 1.  Pharmacotherapy for Seizures in Neonates with Hypoxic Ischemic Encephalopathy.

Authors:  Elissa Yozawitz; Arthur Stacey; Ronit M Pressler
Journal:  Paediatr Drugs       Date:  2017-12       Impact factor: 3.022

Review 2.  Therapeutic drug monitoring in the neonate and paediatric age group. Problems and clinical pharmacokinetic implications.

Authors:  J T Gilman
Journal:  Clin Pharmacokinet       Date:  1990-07       Impact factor: 6.447

3.  Anticonvulsants in the newborn period.

Authors:  N Buchanan
Journal:  Indian J Pediatr       Date:  1985 Sep-Oct       Impact factor: 1.967

4.  Pharmacokinetics and clinical efficacy of phenobarbital in asphyxiated newborns treated with hypothermia: a thermopharmacological approach.

Authors:  M P H van den Broek; F Groenendaal; M C Toet; H L M van Straaten; J G C van Hasselt; A D R Huitema; L S de Vries; A C G Egberts; C M A Rademaker
Journal:  Clin Pharmacokinet       Date:  2012-10-01       Impact factor: 6.447

Review 5.  Effect of Hypothermia and Targeted Temperature Management on Drug Disposition and Response Following Cardiac Arrest: A Comprehensive Review of Preclinical and Clinical Investigations.

Authors:  Kacey B Anderson; Samuel M Poloyac; Patrick M Kochanek; Philip E Empey
Journal:  Ther Hypothermia Temp Manag       Date:  2016-09-13       Impact factor: 1.286

6.  Pharmacokinetics and clinical effect of phenobarbital in children with severe falciparum malaria and convulsions.

Authors:  Gilbert O Kokwaro; Bernhards R Ogutu; Simon N Muchohi; Godfrey O Otieno; Charles R J C Newton
Journal:  Br J Clin Pharmacol       Date:  2003-10       Impact factor: 4.335

Review 7.  Clinical pharmacokinetics of antiepileptic drugs in paediatric patients. Part I: Phenobarbital, primidone, valproic acid, ethosuximide and mesuximide.

Authors:  D Battino; M Estienne; G Avanzini
Journal:  Clin Pharmacokinet       Date:  1995-10       Impact factor: 6.447

Review 8.  Clinical pharmacokinetics in infants and children. A reappraisal.

Authors:  G L Kearns; M D Reed
Journal:  Clin Pharmacokinet       Date:  1989       Impact factor: 6.447

9.  The Effect of Size, Maturation, Global Asphyxia, Cerebral Ischemia, and Therapeutic Hypothermia on the Pharmacokinetics of High-Dose Recombinant Erythropoietin in Fetal Sheep.

Authors:  Simerdeep K Dhillon; Guido Wassink; Christopher A Lear; Joanne O Davidson; Nicholas H G Holford; Alistair J Gunn; Laura Bennet
Journal:  Int J Mol Sci       Date:  2020-04-25       Impact factor: 5.923

10.  Every 36-h gentamicin dosing in neonates with hypoxic-ischemic encephalopathy receiving hypothermia.

Authors:  A Frymoyer; S Lee; S L Bonifacio; L Meng; S S Lucas; B J Guglielmo; Y Sun; D Verotta
Journal:  J Perinatol       Date:  2013-05-23       Impact factor: 2.521
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