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Literature DB >> 6721470

Susceptibilities of bacterial and fungal urinary tract isolates to desferrioxamine.

F D Lowy, S Pollack, N Fadl-Allah, N H Steigbigel.

Abstract

Desferrioxamine, a safe and effective iron chelator, was evaluated for its antibacterial and antifungal activity. The susceptibilities of 124 urinary tract isolates and 28 clinical isolates of Neisseria gonorrhoeae to desferrioxamine concentrations that are readily achievable in urine were determined. Of all isolates, 27% were inhibited by a concentration of less than or equal to 12.5 mM. Proteus mirabilis and N. gonorrhoeae isolates were particularly susceptible to the chelator. Desferrioxamine appears to have limited potential as an antibacterial agent.

Entities: Chemical Species

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Year: 1984 PMID： 6721470 PMCID： PMC185522 DOI： 10.1128/AAC.25.3.375

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

15 in total

Review 1. Iron and infection.

Authors: E D Weinberg
Journal: Microbiol Rev Date: 1978-03

Susceptibilities of bacterial and fungal urinary tract isolates to desferrioxamine.

Review 1. Iron and infection.

2. Iron chelation with oral desferrioxamine.

3. Effect of induced fever on serum iron and ferritin concentrations in man.

4. Editorial retrospective. Iron loading in thalassemia--five years with the pump.

5. Continuous high-dose intravenous desferrioxamine treatment for iron overload.

6. Distribution and renal excretion of desferrioxamine and ferrioxamine in the dog and in the rat.

7. Inhibition of the growth of Neisseria meningitidis by reduced ferritin and other iron-binding agents.

8. Iron as a replacement for mucin in the establishment of meningococcal infection in mice.

9. Enterobacterial chelators of iron: their occurrence, detection, and relation to pathogenicity.

10. Mechanisms of pathogenesis in Listeria monocytogenes infection. I. Influence of iron.

1. Proteobactin and a yersiniabactin-related siderophore mediate iron acquisition in Proteus mirabilis.

2. Iminoguanidines as Allosteric Inhibitors of the Iron-Regulated Heme Oxygenase (HemO) of Pseudomonas aeruginosa.

3. Biofilm-specific uptake of a 4-pyridone-based iron chelator by Pseudomonas aeruginosa.