Literature DB >> 6717891

Effects of Lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study.

C De Martino, T Battelli, M G Paggi, A Nista, M L Marcante, S D'Atri, W Malorni, M Gallo, A Floridi.   

Abstract

Lonidamine induces in murine and human tumor cells severe morphological damage of the mitochondria and other cytoplasmic structures both 'in vitro' and 'in vivo'. Biochemical studies have demonstrated that the drug decreases oxygen consumption and lactate production. The sensitivity of human tumor cells is not related to their histotype. Lonidamine's effects on mitochondria, glycolysis, pentose phosphate pathway, and aromatase activity are discussed.

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Year:  1984        PMID： 6717891     DOI： 10.1159/000225881

Source DB:  PubMed          Journal:  Oncology        ISSN： 0030-2414            Impact factor:   2.935


  8 in total

1.  Modulation of antitumor alkylating agents by novobiocin, topotecan, and lonidamine.

Authors:  G N Schwartz; B A Teicher; J P Eder; T Korbut; S A Holden; G Ara; T S Herman
Journal:  Cancer Chemother Pharmacol       Date:  1993       Impact factor: 3.333

2.  The combined use of radiation therapy and lonidamine in the treatment of brain metastases.

Authors:  L M DeAngelis; V E Currie; J H Kim; G Krol; M A O'Hehir; F M Farag; C W Young; J B Posner
Journal:  J Neurooncol       Date:  1989-09       Impact factor: 4.130

3.  Effect of lonidamine on the cytotoxicity of four alkylating agents in vitro.

Authors:  K W Rosbe; T W Brann; S A Holden; B A Teicher; E Frei
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

4.  Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification.

Authors:  O Ben-Yoseph; J C Lyons; C W Song; B D Ross
Journal:  J Neurooncol       Date:  1998-01       Impact factor: 4.130

5.  Fluosol-DA/carbogen with lonidamine or pentoxifylline as modulators of alkylating agents in the FSaIIC fibrosarcoma.

Authors:  B A Teicher; T S Herman; J Tanaka; B Dezube; A Pardee; E Frei
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

6.  Lactic dehydrogenase isozymes, 31P magnetic resonance spectroscopy, and in vitro antimitochondrial tumor toxicity with gossypol and rhodamine-123.

Authors:  C Benz; C Hollander; M Keniry; T L James; M Mitchell
Journal:  J Clin Invest       Date:  1987-02       Impact factor: 14.808

7.  In vitro potentiation by lonidamine of the cytotoxic effect of adriamycin on primary and established breast cancer cell lines.

Authors:  S Savini; W Zoli; O Nanni; A Volpi; G L Frassineti; E Magni; A Flamigni; A Amadori; D Amadori
Journal:  Breast Cancer Res Treat       Date:  1992       Impact factor: 4.872

8.  Relative cytotoxicities of adriamycin and epirubicin in combination with lonidamine against human bladder cancer cell lines.

Authors:  R J Popert; J R Masters; M Coptcoat; G Zupi
Journal:  Urol Res       Date:  1995
  8 in total

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