| Literature DB >> 6717030 |
S T Kau, J R Keddie, D Andrews.
Abstract
A reproducible screening method for diuretic agents has been developed based upon the selection of a group of homogenous rats with a similar excretory pattern of water and electrolytes. Normal saline (4% body weight) was used as a hydrating fluid to select appropriate rats and to validate the diuretic activity of standard diuretics. The method required only a small number of rats for screening compounds and produced consistent responses in increasing water and electrolyte excretion.Entities:
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Year: 1984 PMID： 6717030 DOI： 10.1016/0160-5402(84)90054-8
Source DB: PubMed Journal: J Pharmacol Methods ISSN： 0160-5402