Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 T-T interactions in the induction of suppressor and helper T cells: analysis of membrane phenotype of precursor and amplifier cells.

Literature DB >> 67169

T-T interactions in the induction of suppressor and helper T cells: analysis of membrane phenotype of precursor and amplifier cells.

M Feldmann, P C Beverley, J Woody, I F McKenzie.

Abstract

The Ly and Ia phenotypes of T lymphocytes involved in the in vitro generation of helper and suppressor cells were identified. The precursors of both cells are found in adult thymectomized spleen. Helper precursors are Ly-1+2-3-Ia-, while suppressor precursors are Ly-1-2+3+Ia-, although the suppressor effector is Ia+. In both cases a second 'amplifier' cell is required for differentiation of precursors to occur. This cell is found in anti-lymphocyte serum-treated spleen and has the phenotype Ly-1+2+3+Ia-.

Mesh：

Substances：

Year: 1977 PMID： 67169 PMCID： PMC2180645 DOI： 10.1084/jem.145.4.793

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

20 in total

1. Role of macrophages in in vitro induction of T-helper cells.

Authors: P Erb; M Feldmann
Journal: Nature Date: 1975-03-27 Impact factor: 49.962

2. Different Ly antigen phenotypes of in vitro induced helper and suppressor cells.

Authors: M Feldmann; P C Beverley; M Dunkley; S Kontiainen
Journal: Nature Date: 1975-12-18 Impact factor: 49.962

3. Regulation of the immune response by subclasses of T lymphocytes. II. The effect of adult thymectomy upon humoral and cellular responses in mice.

Authors: E Simpson; H Cantor
Journal: Eur J Immunol Date: 1975-05 Impact factor: 5.532

4. Separation of suppressor and killer T cells by surgace phenotype.

Authors: P C Beverley; J Woody; M Dunkley; M Feldmann; I McKenzie
Journal: Nature Date: 1976-08-05 Impact factor: 49.962

5. Suppressor cell induction in vitro. II. Cellular requirements of suppressor cell induction.

Authors: M Feldmann; S Kontiainen
Journal: Eur J Immunol Date: 1976-04 Impact factor: 5.532

6. Role of macrophages in the generation of T helper cells. IV. Nature of genetically related factor derived from macrophages incubated with soluble antigens.

Authors: P Erb; M Feldmann; N Hogg
Journal: Eur J Immunol Date: 1976-05 Impact factor: 5.532

7. Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.

Authors: H Cantor; E A Boyse
Journal: J Exp Med Date: 1975-06-01 Impact factor: 14.307

8. A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes.

Authors: D B Murphy; L A Herzenberg; K Okumura; L A Herzenberg; H O McDevitt
Journal: J Exp Med Date: 1976-09-01 Impact factor: 14.307

9. Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses.

Authors: H Cantor; F W Shen; E A Boyse
Journal: J Exp Med Date: 1976-06-01 Impact factor: 14.307

10. Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity.

Authors: H Cantor; E A Boyse
Journal: J Exp Med Date: 1975-06-01 Impact factor: 14.307

36 in total

1. Inhibition of humoral and cell-mediated immune responses in man by distinct suppressor cell systems.

Authors: P I Lobo; C E Spencer
Journal: J Clin Invest Date: 1979-06 Impact factor: 14.808

2. Surface markers on the T cells that regulate cytotoxic T-cell responses I. The Ly phenotype of suppressor T cells changes as a function of time, and is distinct from that of helper or cytotoxic T cells.

Authors: A R Al-Adra; L M Pilarski; I F McKenzie
Journal: Immunogenetics Date: 1980 Impact factor: 2.846

9. Delayed hypersensitivity responses to human IgG and methylated bovine serum albumin are regulated by different mechanisms.

Authors: C Clark; A P Dalmasso
Journal: Immunology Date: 1982-09 Impact factor: 7.397

10. Antigen- and receptor-driven regulatory mechanisms. VII. H-2-restricted anti-idiotypic suppressor factor from efferent suppressor T cells.

Authors: M H Dietz; M S Sy; B Benacerraf; A Nisonoff; M I Greene; R N Germain
Journal: J Exp Med Date: 1981-02-01 Impact factor: 14.307