Literature DB >> 6716249

Improved delivery through biological membranes XIV: Brain-specific, sustained delivery of testosterone using a redox chemical delivery system.

N Bodor, H H Farag.   

Abstract

The dihydropyridine in equilibrium pyridinium salt redox delivery system was used for the specific delivery and sustained release of testosterone in the brain. Administration of the N-methyl-1,4-dihydro nicotinate ester of testosterone in female rats gave high and sustained brain levels of the corresponding quaternary ester, testosterone trigonellinate. This contrasted with rapid elimination from the general circulation. Release of testosterone "locked into" brain as the quaternary salt was sustained, t1/2 = 20 h.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6716249     DOI： 10.1002/jps.2600730324

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  6 in total

1.  A redox-based system that enhances delivery of estradiol to the brain: pharmacokinetic evaluation in the dog.

Authors:  K Dietzel; V Keuth; K S Estes; M E Brewster; R M Clemmons; R Vistelle; N S Bodor; H Derendorf
Journal:  Pharm Res       Date:  1990-08       Impact factor: 4.200

2.  Improved Delivery Through Biological Membranes. XXIV. Synthesis, in Vitro Studies, and in Vivo Characterization of Brain-Specific and Sustained Progestin Delivery Systems.

Authors:  M E Brewster; K S Estes; N Bodor
Journal:  Pharm Res       Date:  1986-10       Impact factor: 4.200

3.  In vitro and in vivo investigations of dihydropyridine-based chemical delivery systems for anticonvulsants.

Authors:  A V Boddy; K Zhang; F Lepage; F Tombret; J G Slatter; T A Baillie; R H Levy
Journal:  Pharm Res       Date:  1991-06       Impact factor: 4.200

4.  High-performance liquid chromatographic assay of a central nervous system (CNS)-directed estradiol chemical delivery system and its application after intravenous administration to rats.

Authors:  G Mullersman; H Derendorf; M E Brewster; K S Estes; N Bodor
Journal:  Pharm Res       Date:  1988-03       Impact factor: 4.200

5.  Anxiolytic activity of a brain delivery system for GABA.

Authors:  W R Anderson; J W Simpkins; P A Woodard; D Winwood; W C Stern; N Bodor
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

6.  Application of a brain-targeting chemical delivery system to 9-amino-1,2,3,4-tetrahydroacridine.

Authors:  E Pop; K Prókai-Tátrai; J D Scott; M E Brewster; N Bodor
Journal:  Pharm Res       Date:  1990-06       Impact factor: 4.200
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.