Literature DB >> 6715467

High-performance liquid chromatographic method for the determination of N-methylated metabolites of nicotine.

K C Cundy, P A Crooks.   

Abstract

An analytical method has been developed, using cation-exchange high-performance liquid chromatography, for the analysis of N-methylated metabolites of nicotine. This method has been used to detect and quantitate seven potential in vivo urinary metabolites of [2'-14C]-nicotine, including four methylated nicotine derivatives, in the guinea pig.

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Year:  1984        PMID： 6715467     DOI： 10.1016/s0378-4347(00)80891-9

Source DB:  PubMed          Journal:  J Chromatogr


  5 in total

1.  Trans-3'-hydroxycotinine as a main metabolite in urine of smokers.

Authors:  G B Neurath; M Dünger; D Orth; F G Pein
Journal:  Int Arch Occup Environ Health       Date:  1987       Impact factor: 3.015

2.  Nicotine pharmacokinetics in rats is altered as a function of age, impacting the interpretation of animal model data.

Authors:  Evelyn L Craig; Bin Zhao; Jason Z Cui; Maria Novalen; Sharon Miksys; Rachel F Tyndale
Journal:  Drug Metab Dispos       Date:  2014-06-30       Impact factor: 3.922

3.  Blood-brain barrier penetration abolished by N-methyl quaternization of nicotine.

Authors:  W H Oldendorf; B E Stoller; F L Harris
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-01       Impact factor: 11.205

4.  Age-related differences in the disposition of nicotine and metabolites in rat brain and plasma.

Authors:  Paula L Vieira-Brock; David M Andrenyak; Shannon M Nielsen; Annette E Fleckenstein; Diana G Wilkins
Journal:  Nicotine Tob Res       Date:  2013-06-04       Impact factor: 4.244

5.  Metabolism of S-nicotine in noninduced and aroclor-induced rats.

Authors:  G Schepers; K Rustemeier; R A Walk; U Hackenberg
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1993 Apr-Jun       Impact factor: 2.441
  5 in total

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