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Literature DB >> 6714854

Antimicrobial effects of esters and amides of 3-(5-nitro-2-furyl)acrylic acid.

G Kellová, E Sturdík, L Stibrányi, L Drobnica, J Augustín.

Abstract

The effect of 18 newly synthesized esters and amides of 3-(5-nitro-2-furyl)acrylic acid on bacteria (Escherichia coli, Staphylococcus aureus), yeasts (Saccharomyces cerevisiae, Candida albicans), molds (Aspergillus niger, Penicillium cyclopium, Rhizopus oryzae) and algae (Chlorella pyrenoidosa, Euglena gracilis, Scenedesmus obliquus) was investigated. The MIC values revealed antimycotic, antialgal and antibacterial activity of the studied derivatives. The antimycotic activity was found to decrease with increasing the length of the alkyl chain of esters and after introduction of amino nitrogen into the furylethylene backbone. The inhibitory effect on growth is caused by blocking bioenergetic processes, glycolysis in particular.

Entities: Chemical Species

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Year: 1984 PMID： 6714854 DOI： 10.1007/bf02875905

Source DB: PubMed Journal: Folia Microbiol (Praha) ISSN： 0015-5632 Impact factor: 2.099

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References

12 in total

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Antimicrobial effects of esters and amides of 3-(5-nitro-2-furyl)acrylic acid.

1. Action of some nitrofuran derivatives on glucose metabolism, ATP levels, and macromolecule synthesis in Escherichia coli.

2. Relationships between the carcinogenic and mutagenic or DNA-modifying effects of nitrofuran derivatives, including 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide, a food additive.

Review 3. Chemotherapeutic properties of heterocyclic compounds: monocyclic compounds with five-membered rings.

4. Editorial: AF-2--food preservative or genetic hazard?

5. The influence of dimethyl sulphoxide on metabolic activity of ehrlich ascites carcinoma cells and microorganisms.

Review 6. The nitrofurans.

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