| Literature DB >> 671450 |
W C Lumma, R D Hartman, W S Saari, E L Engelhardt, R Hirschmann, B V Clineschmidt, M L Torchiana, C A Stone.
Abstract
A series of 2-(1-piperazinyl)pyrazines was synthesized and evaluated for central serotonin-like activity. The most interesting member of the series, 6-chloro-2(1-piperazinyl)pyrazine (3a), had pharmacological properties characteristic of potent central serotoninmimetic activity and only weak peripheral serotoninmimetic action. Structural similarities between 3a and serotonin are discussed.Entities:
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Year: 1978 PMID： 671450 DOI： 10.1021/jm00204a007
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446