| Literature DB >> 6714368 |
G Pallavicini, A Bardoni, A Profumo, A A Castellani, P Schiatti, A Glässer.
Abstract
Oral administration to fasted rats of absolute ethanol produces extensive necrotic lesions of gastric mucosa as well as a massive leakage of proteins and mucus glycoproteins into gastric lumen. When the new synthetic prostaglandin MDL 646, belonging to the PGE1 series, is administered intragastrically (2 or 10 micrograms/kg) 30 min before ethanol administration, a significant protection of rat gastric mucosa against alcohol injury is observed.Entities:
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Year: 1984 PMID： 6714368 DOI： 10.1007/bf01952558
Source DB: PubMed Journal: Experientia ISSN： 0014-4754