Literature DB >> 6714367

Mitochondrial and cytosolic glutathione after depletion by phorone in isolated hepatocytes.

F J Romero, S Soboll, H Sies.   

Abstract

The glutathione content of cytosol and mitochondria of isolated hepatocytes was depleted by addition of a low concentration of phorone (0.5 mM) by 75% and 40% respectively. Different rates of replenishment indicate metabolic separation of cytosolic and mitochondrial glutathione pools. The release from hepatocytes occurred at a rate of about 8 nmol/g wet weight/min, both in controls and after phorone depletion.

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Year:  1984        PMID： 6714367     DOI： 10.1007/bf01952555

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  17 in total

1.  Decrease in glutathione levels of kidney and liver after injection of methionine sulfoximine into rats.

Authors:  A G Palekar; S S Tate; A Meister
Journal:  Biochem Biophys Res Commun       Date:  1975-02-03       Impact factor: 3.575

2.  Rapid separation of particulate components and soluble cytoplasm of isolated rat-liver cells.

Authors:  P F Zuurendonk; J M Tager
Journal:  Biochim Biophys Acta       Date:  1974-02-22

3.  Blood and liver glutathione during protein deprivation.

Authors:  S EDWARDS; W W WESTERFELD
Journal:  Proc Soc Exp Biol Med       Date:  1952-01

4.  Some properties of mitochondrial glutathione.

Authors:  P C Jocelyn
Journal:  Biochim Biophys Acta       Date:  1975-09-08

5.  Reduced and oxidized glutathione efflux from liver.

Authors:  G M Bartoli; H Sies
Journal:  FEBS Lett       Date:  1978-02-01       Impact factor: 4.124

6.  The role of methionine in glutathione biosynthesis by isolated hepatocytes.

Authors:  D J Reed; S Orrenius
Journal:  Biochem Biophys Res Commun       Date:  1977-08-22       Impact factor: 3.575

7.  The non-protein thiol of rat liver mitochondria.

Authors:  P C Jocelyn; A Kamminga
Journal:  Biochim Biophys Acta       Date:  1974-04-22

8.  Subcellular metabolite concentrations. Dependence of mitochondrial and cytosolic ATP systems on the metabolic state of perfused rat liver.

Authors:  S Soboll; R Scholz; H W Heldt
Journal:  Eur J Biochem       Date:  1978-06-15

9.  Regulation of hepatic glutathione turnover in rats in vivo and evidence for kinetic homogeneity of the hepatic glutathione pool.

Authors:  B H Lauterburg; J R Mitchell
Journal:  J Clin Invest       Date:  1981-05       Impact factor: 14.808

10.  High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.

Authors:  M N Berry; D S Friend
Journal:  J Cell Biol       Date:  1969-12       Impact factor: 10.539
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  3 in total

1.  Glutathione replenishment capacity is lower in isolated perivenous than in periportal hepatocytes.

Authors:  Y Kera; K E Penttilä; K O Lindros
Journal:  Biochem J       Date:  1988-09-01       Impact factor: 3.857

2.  Brain mitochondrial alterations after chronic alcohol consumption.

Authors:  I Almansa; A Fernández; C García-Ruiz; M Muriach; J M Barcia; M Miranda; J C Fernández-Checa; F J Romero
Journal:  J Physiol Biochem       Date:  2009-09       Impact factor: 4.158

3.  Inhibition of the low-Km mitochondrial aldehyde dehydrogenase by diethyl maleate and phorone in vivo and in vitro. Implications for formaldehyde metabolism.

Authors:  E Dicker; A I Cederbaum
Journal:  Biochem J       Date:  1986-12-15       Impact factor: 3.857
  3 in total

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