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Literature DB >> 6714022

Synchronous DNA synthesis and mitosis in multinucleate cells with one chromosome in each nucleus.

Abstract

Multinucleate cells were induced by colcemid treatment in PtK1 cells in culture. DNA synthesis and mitotic behavior of those cells in which each nucleus contained a single chromosome were studied. More than 80% of such cells showed synchronous DNA synthesis and mitosis in all nuclei. As these genetically different nuclei respond identically to the molecules that initiate DNA synthesis and mitosis, intranuclear control of initiation of DNA synthesis and induction of mitosis by genes on individual chromosomes can be excluded. The occasional occurrence of asynchronous division in multinucleate cells is assumed to result from unequal availability of the inducer molecules to the individual nuclei.

Entities: Gene

Mesh：

Substances：
DNA
Demecolcine

Year: 1984 PMID： 6714022 DOI： 10.1007/bf00294999

Source DB: PubMed Journal: Chromosoma ISSN： 0009-5915 Impact factor: 4.316

18 in total

1. A possible role for histone in the synthesis of DNA.

Authors: H Weintraub
Journal: Nature Date: 1972-12-22 Impact factor: 49.962

2. Mitosis in flat PTK2-human hybrid cells.

Authors: S P Peterson; M W Berns
Journal: Exp Cell Res Date: 1979-05 Impact factor: 3.905

Review 3. Nucleo-cytoplasmic interactions in the acheivement of nuclear synchrony in DNA synthesis and mitosis in multinucleate cells.

Authors: R T Johnson; P N Rao
Journal: Biol Rev Camb Philos Soc Date: 1971-02

4. A low-viscosity epoxy resin embedding medium for electron microscopy.

Authors: A R Spurr
Journal: J Ultrastruct Res Date: 1969-01

5. Mammalian cell fusion: studies on the regulation of DNA synthesis and mitosis.

Authors: P N Rao; R T Johnson
Journal: Nature Date: 1970-01-10 Impact factor: 49.962

6. Mitotic factors from mammalian cells induce germinal vesicle breakdown and chromosome condensation in amphibian oocytes.

Authors: P S Sunkara; D A Wright; P N Rao
Journal: Proc Natl Acad Sci U S A Date: 1979-06 Impact factor: 11.205

7. Multinucleate plant cells. II. Requirements for nuclear DNA synthesis.

Authors: J P Hervás; J F López-Sáez; G Giménez-Martín
Journal: Exp Cell Res Date: 1982-06 Impact factor: 3.905

8. DNA synthesis and mitosis in fused cells. I. HeLa homokaryons.

Authors: R T Johnson; H Harris
Journal: J Cell Sci Date: 1969-11 Impact factor: 5.285

9. Membranes in the mitotic apparatus of barley cells.

Authors: P K Hepler
Journal: J Cell Biol Date: 1980-08 Impact factor: 10.539

10. Asynchrony of nuclear development in cytochalasin-induced multinucleate cells.

Authors: A Krishan; R Ray-Chaudhuri
Journal: J Cell Biol Date: 1969-12 Impact factor: 10.539

8 in total

1. Spontaneous chromosome doubling results from nuclear fusion during in vitro maize induced microspore embryogenesis.

Authors: P Testillano; S Georgiev; H L Mogensen; M J Coronado; C Dumas; M C Risueno; E Matthys-Rochon
Journal: Chromosoma Date: 2004-05-11 Impact factor: 4.316

2. Mitosis in vertebrate somatic cells with two spindles: implications for the metaphase/anaphase transition checkpoint and cleavage.

Authors: C L Rieder; A Khodjakov; L V Paliulis; T M Fortier; R W Cole; G Sluder
Journal: Proc Natl Acad Sci U S A Date: 1997-05-13 Impact factor: 11.205

3. Indirect mitotic nondisjunction in Vicia faba and Chinese hamster cells.

Authors: M Rizzoni; C Tanzarella; B Gustavino; F Degrassi; A Guarino; E Vitagliano
Journal: Chromosoma Date: 1989-01 Impact factor: 4.316

4. Events associated with the initiation of mitosis in fused multinucleate HeLa cells.

Authors: S Ghosh; N Paweletz
Journal: Chromosoma Date: 1984 Impact factor: 4.316

5. Categorization of micronuclei by size and measurement of each ratio in cytokinesis-block and conventional cultures of human lymphocytes exposed to mitomycin C and colchicine.

Authors: K Mure; T Takeshita; K Morimoto
Journal: Environ Health Prev Med Date: 1996-07 Impact factor: 3.674