Literature DB >> 671345

The febrile responses in rabbits and rats to leucocyte pyrogens of different species.

D Borsook, H Laburn, D Mitchell.   

Abstract

1. We have investigated the effects on body temperature of rats and rabbits of leucocyte pyrogen derived from the blood of rat, rabbit, ox, pig and baboon. 2. In the rabbit intravenous injections (3.5 ml.) of solutions containing leucocyte pyrogen derived from ox, pig and rabbit blood produced fevers with short latencies; no fevers resulted from injections of similar solutions derived from rat or baboon blood. 3. In the rat intraperitoneal injections (2.0 ml.) of solutions containing leucocyte pyrogen derived from ox blood caused a fever, while pig leucocyte pyrogen produced a marked hypothermia. Neither rabbit, baboon, nor rat leucocyte pyrogen had any significant effect on rectal temperature of the rats. 4. Our results show that there is a variability of response in the rat and the rabbit to injection of leucocyte pyrogen of different species; leucocyte pyrogen may be species specific.

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Year:  1978        PMID： 671345      PMCID： PMC1282604          DOI： 10.1113/jphysiol.1978.sp012333

Source DB:  PubMed          Journal:  J Physiol        ISSN： 0022-3751            Impact factor:   5.182


  22 in total

1.  Studies on the pathogenesis of fever. VII. Comparative observations on the production of fever by inflammatory exudates in rabbits and dogs.

Authors:  R G PETERSDORF; I L BENNETT
Journal:  Bull Johns Hopkins Hosp       Date:  1957-06

2.  Studies on the pathogenesis of fever. VIII. Fever-producing substances in the serum of dogs.

Authors:  R G PETERSDORF; I L BENNETT
Journal:  J Exp Med       Date:  1957-08-01       Impact factor: 14.307

3.  Fever induced with leucocytic or bacterial pyrogen in young and adult goats.

Authors:  A S van Miert; A Atmakusuma
Journal:  J Comp Pathol       Date:  1971-01       Impact factor: 1.311

4.  The reaction of different animal species to bacterial pyrogens.

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Journal:  Zentralbl Veterinarmed A       Date:  1968

5.  Assay of human endogenous pyrogen.

Authors:  W I Cranston; R H Luff; M D Rawlins
Journal:  J Physiol       Date:  1971-05       Impact factor: 5.182

Review 6.  Monoamines, pyrogens and cations: their actions on central control of bodytemperature.

Authors:  R F Hellon
Journal:  Pharmacol Rev       Date:  1974-12       Impact factor: 25.468

7.  Comparative observations on the production of fever by bacterial pyrogens and leucocytic pyrogen in goats and rabbits.

Authors:  A S Van Miert; A Atmakusuma
Journal:  Zentralbl Veterinarmed A       Date:  1970-02

8.  Prostaglandins, endotoxin and lipid A on body temperature in rats.

Authors:  W Feldberg; P N Saxena
Journal:  J Physiol       Date:  1975-08       Impact factor: 5.182

9.  Persistence of febrile response to pyrogens after PO/AH lesions in squirrel monkeys.

Authors:  J M Lipton; G P Trzcinka
Journal:  Am J Physiol       Date:  1976-12

10.  Studies on the pathogenesis of fever. XI. Quantitative features of the febrile response to leucocytic pyrogen.

Authors:  D L BORNSTEIN; C BREDENBERG; W B WOOD
Journal:  J Exp Med       Date:  1963-03-01       Impact factor: 14.307
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  7 in total

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Journal:  Br J Pharmacol       Date:  1980       Impact factor: 8.739

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Authors:  D M Ford; K P Klugman
Journal:  J Physiol       Date:  1980-07       Impact factor: 5.182

3.  Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide.

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Journal:  J Physiol       Date:  1980-03       Impact factor: 5.182

5.  Implications of leukocytosis and fever at conclusion of antibiotic therapy for intra-abdominal sepsis.

Authors:  E S Lennard; E P Dellinger; M J Wertz; B H Minshew
Journal:  Ann Surg       Date:  1982-01       Impact factor: 12.969

6.  Fever induced in rabbits by intravenous injection of bovine serum albumin.

Authors:  J Hattingh; H Laburn; D Mitchell
Journal:  J Physiol       Date:  1979-05       Impact factor: 5.182

7.  The effect of low ambient temperature on the febrile responses of rats to semi-purified human endogenous pyrogen.

Authors:  J T Stitt; S G Shimada
Journal:  Yale J Biol Med       Date:  1985 Mar-Apr
  7 in total

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