Literature DB >> 6712912

Experimental model of proliferative vitreoretinopathy (PVR) in the vitrectomised eye: effect of silicone oil.

J S Lean, W A van der Zee, S J Ryan.   

Abstract

Silicone oil alone or as an adjunct to vitrectomy is widely used for the treatment of retinal detachment complicated by proliferative vitreoretinopathy (PVR). It appears to reduce the tendency for recurrent traction detachment, but the mechanism of this action is obscure. We have studied the effects of silicone oil in an experimental animal model. Twenty five thousand homologous fibroblasts were injected into the aphakic vitrectomised rabbit eye, and traction detachment of the vascularised retina (medullary rays) regularly resulted. Intraocular silicone oil did not influence the development of this experimental detachment.

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Year:  1984        PMID： 6712912      PMCID： PMC1040334          DOI： 10.1136/bjo.68.5.332

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN： 0007-1161            Impact factor:   4.638


  14 in total

1.  Pathology of vitreous membranes and the effect of haemorrhage and new vessels on the vitreous.

Authors:  I J Constable
Journal:  Trans Ophthalmol Soc U K       Date:  1975

2.  Geometry of intraocular gas used in retinal surgery.

Authors:  L M Parver; H Lincoff
Journal:  Mod Probl Ophthalmol       Date:  1977

3.  Ultrastructure of epiretinal membranes causing macular pucker after retinal re-attachment surgery.

Authors:  W R Green; K R Kenyon; R G Michels; H D Gilbert; Z De La Cruz
Journal:  Trans Ophthalmol Soc U K       Date:  1979-04

4.  Massive periretinal proliferation: a logical approach to therapy.

Authors:  R Machemer
Journal:  Trans Am Ophthalmol Soc       Date:  1977

5.  Clinical-pathological correlation in massive periretinal proliferation.

Authors:  H Laqua; R Machemer
Journal:  Am J Ophthalmol       Date:  1975-11       Impact factor: 5.258

6.  Glial cell proliferation in human retinal detachment with massive periretinal proliferation.

Authors:  D L Van Horn; T M Aaberg; R Machemer; R Fenzl
Journal:  Am J Ophthalmol       Date:  1977-09       Impact factor: 5.258

7.  Pigment epithelial proliferation in human retinal detachment with massive periretinal proliferation.

Authors:  R Machemer; D van Horn; T M Aaberg
Journal:  Am J Ophthalmol       Date:  1978-02       Impact factor: 5.258

8.  Epiretinal and vitreous membranes. Comparative study of 56 cases.

Authors:  A Kampik; K R Kenyon; R G Michels; W R Green; Z C de la Cruz
Journal:  Arch Ophthalmol       Date:  1981-08

9.  Role of cell shape in growth control.

Authors:  J Folkman; A Moscona
Journal:  Nature       Date:  1978-06-01       Impact factor: 49.962

10.  Human massive periretinal proliferation. In vitro characteristics of cellular components.

Authors:  D A Newsome; M M Rodrigues; R Machemer
Journal:  Arch Ophthalmol       Date:  1981-05
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  5 in total

Review 1.  Proliferative vitreoretinopathy: pathobiology, surgical management, and adjunctive treatment.

Authors:  D G Charteris
Journal:  Br J Ophthalmol       Date:  1995-10       Impact factor: 4.638

Review 2.  Proliferative vitreoretinopathy--is it anything more than wound healing at the wrong place?

Authors:  M Weller; P Wiedemann; K Heimann
Journal:  Int Ophthalmol       Date:  1990-03       Impact factor: 2.031

3.  Connective tissue growth factor as a mediator of intraocular fibrosis.

Authors:  Shikun He; Youxin Chen; Rima Khankan; Ernesto Barron; Richard Burton; Danhong Zhu; Stephen J Ryan; Noelynn Oliver; David R Hinton
Journal:  Invest Ophthalmol Vis Sci       Date:  2008-04-30       Impact factor: 4.799

4.  Randomized clinical trial of intraocular silicone vs. gas in the management of complicated retinal detachment and vitreous hemorrhage.

Authors:  G A Peyman; G W Kao; L R de Corral
Journal:  Int Ophthalmol       Date:  1987-08       Impact factor: 2.031

5.  Regular silicone and fluorosilicone oil in the prevention of retinal detachment caused by experimental proliferative vitreoretinopathy.

Authors:  A Alghadyan; G A Peyman; C Fizer; M Tawakol; K R Liu; B Yue; J H Peace
Journal:  Int Ophthalmol       Date:  1988-01       Impact factor: 2.031
  5 in total

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