Literature DB >> 6712888

The pathogenesis of amiodarone-induced pigmentation and photosensitivity.

C B Zachary, D N Slater, D W Holt, G C Storey, D M MacDonald.   

Abstract

A new method has been used to measure tissue levels of amiodarone and its major metabolite desethylamiodarone. Amiodarone-pigmented skin has a drug and metabolite concentration ten times that of non-pigmented skin. Iodine-rich amiodarone and its metabolite have been detected in secondary lysosomes by energy dispersive analysis of X-rays. Amiodarone induces a phototoxic reaction with an action spectrum in both the UV-B and UV-A wavelengths.

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Year:  1984        PMID： 6712888     DOI： 10.1111/j.1365-2133.1984.tb04660.x

Source DB:  PubMed          Journal:  Br J Dermatol        ISSN： 0007-0963            Impact factor:   9.302


  6 in total

1.  [Hyperpigmentation of the face].

Authors:  J Dissemond; T Franckson; G Fitz; U Hillen; M Goos
Journal:  Hautarzt       Date:  2003-08-21       Impact factor: 0.751

Review 2.  Risk-benefit assessment of amiodarone in the treatment of cardiac arrhythmias.

Authors:  P J Counihan; W J McKenna
Journal:  Drug Saf       Date:  1990 Jul-Aug       Impact factor: 5.606

Review 3.  Drug-induced photosensitivity: culprit drugs, management and prevention.

Authors:  Aaron M Drucker; Cheryl F Rosen
Journal:  Drug Saf       Date:  2011-10-01       Impact factor: 5.606

4.  Side effects with amiodarone therapy.

Authors:  R Shukla; N I Jowett; D R Thompson; J E Pohl
Journal:  Postgrad Med J       Date:  1994-07       Impact factor: 2.401

Review 5.  Cutaneous adverse reactions of amiodarone.

Authors:  Krzysztof Jaworski; Irena Walecka; Lidia Rudnicka; Maciej Gnatowski; Dariusz A Kosior
Journal:  Med Sci Monit       Date:  2014-11-21

6.  Intra-Articular Pigmentation of Synovium: An Unusual Cause.

Authors:  Shobhit Verma; Steven Hamilton; Sue M Liew
Journal:  Clin Orthop Surg       Date:  2016-08-10
  6 in total

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