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Literature DB >> 6712620

Effect of thioacetamide on cytochrome P-450 synthesis in rat liver.

Abstract

A single injection of thioacetamide to rats results in a striking decrease in liver cytochrome P-450. The drug blocks the phenobarbitone-mediated induction of cytochrome P-450b. Under these conditions, there is a decrease in the synthesis of cytochrome P-450b, which is essentially due to a decrease in the amount of translatable mRNA for cytochrome P-450b. This effect of thioacetamide is not due to a general effect on protein synthesis or polyribosome stability. Multiple injections of thioacetamide also decrease the synthesis of cytochrome P-450b and the amounts of its translatable mRNA.

Entities: Chemical Gene Species

Mesh：

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Year: 1984 PMID： 6712620 PMCID： PMC1153350 DOI： 10.1042/bj2180371

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

26 in total

1. Preparation of monospecific antibodies against two forms of rat liver cytochrome P-450 and quantitation of these antigens in microsomes.

Authors: P E Thomas; D Korzeniowski; D Ryan; W Levin
Journal: Arch Biochem Biophys Date: 1979-02 Impact factor: 4.013

2. THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.

Authors: T OMURA; R SATO
Journal: J Biol Chem Date: 1964-07 Impact factor: 5.157

3. EFFECTS OF THIOACETAMIDE AND YELLOW PHOSPHORUS POISONING ON PROTEIN SYNTHESIS IN VIVO.

Authors: E A BARKER; E A SMUCKLER; E P BENDITT
Journal: Lab Invest Date: 1963-10 Impact factor: 5.662

4. Liver Tumors in Rats Fed Thiourea or Thioacetamide.

Authors: O G Fitzhugh; A A Nelson
Journal: Science Date: 1948-12-03 Impact factor: 47.728

5. Nucleoli of thioacetamide-treated liver as a model for studying regulation of preribosomal RNA synthesis.

Authors: M W Andersen; N R Ballal; H Busch
Journal: Biochem Biophys Res Commun Date: 1977-09-09 Impact factor: 3.575

6. Cytochrome P-450 synthesis in vivo and in a cell-free system from rat liver.

Authors: K S Bhat; G Padmanaban
Journal: FEBS Lett Date: 1978-05-15 Impact factor: 4.124

7. A simple and rapid procedure for the purification of phenobarbital-inducible cytochrome P-450 from rat liver microsomes.

Authors: S B West; M T Huang; G T Miwa; A Y Lu
Journal: Arch Biochem Biophys Date: 1979-03 Impact factor: 4.013

8. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors: U K Laemmli
Journal: Nature Date: 1970-08-15 Impact factor: 49.962

9. Increased activity of rat liver messenger RNA and of albumin messenger RNA modulated by thioacetamide.

Authors: P K Chakrabartty; W C Schneider
Journal: Cancer Res Date: 1978-07 Impact factor: 12.701

10. Effects of thioacetamide treatment on nuclear envelope nucleoside triphosphatase activity and transport of RNA from rat liver nuclei.

Authors: G A Clawson; M Koplitz; D E Moody; E A Smuckler
Journal: Cancer Res Date: 1980-01 Impact factor: 12.701

4 in total