Literature DB >> 671258

Differential plus polarographic determination of submicrogram quantities of carmustine and related compounds in biological samples.

I Bartosek, S Daniel, S Sýkora.   

Abstract

A polarographic method was developed to determine the antineoplastic agent carmustine and other nitrosoureas, such as N-methyl-N-nitrosourea and N-cyclohexyl-N-nitrosourea, in biological fluids at levels well below 1 microgram/ml or g. The stability of carmustine in different media was investigated to prevent losses during administration or assay. Examples of nitrosourea determination in biological samples are given.

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Year:  1978        PMID： 671258     DOI： 10.1002/jps.2600670836

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  4 in total

1.  Capillary gas chromatography and thermionic N-P-specific detection of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) or 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in stability and pharmacokinetic studies.

Authors:  A El-Yazigi; C R Martin
Journal:  Pharm Res       Date:  1988-04       Impact factor: 4.200

2.  Distribution of 13N in rat tissues following intravenous administration of nitroso-labeled BCNU.

Authors:  B R Freed; R L McQuinn; R S Tilbury; G A Digenis
Journal:  Cancer Chemother Pharmacol       Date:  1982-12       Impact factor: 3.333

3.  Pharmacokinetics of fotemustine and BCNU in plasma, liver and tumor tissue of rats bearing two lines of Walker 256 carcinoma.

Authors:  A Guaitani; M Corada; C Lucas; A Lemoine; S Garattini; I Bartosek
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

Review 4.  Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. General considerations, the nitrosoureas and alkylating agents.

Authors:  A G Bosanquet
Journal:  Cancer Chemother Pharmacol       Date:  1985       Impact factor: 3.333
  4 in total

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