Literature DB >> 6712289

Changes in normal polymorphonuclear leucocyte motility after ingestion of IgG aggregates.

D H Goddard, A P Kirk, K A Brown, D McCarthy, G D Johnson, E J Holborow.   

Abstract

Changes in normal polymorphonuclear leucocyte (PMN) motility after membrane-binding and internalisation of IgG aggregates (a model of soluble immune complexes) have been studied by the micropore filter assay. The results have confirmed that IgG aggregates stimulate as well as inhibit PMN chemotaxis. These effects are dependent on the size and concentration of the IgG aggregates in solution as well as the length of time of incubation. Stimulated chemotaxis was observed in a small subset of the whole PMN population which was apparent only when cell distribution through the filters was analysed. These results indicate the need for caution when drawing conclusions about PMN function from results obtained by these assay techniques.

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Substances：

Year:  1984        PMID： 6712289      PMCID： PMC1001452          DOI： 10.1136/ard.43.2.146

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  9 in total

1.  Locomotion and adhesion of neutrophil granulocytes. Effects of albumin, fibrinogen and gamma globulins studied by reflection contrast microscopy.

Authors:  H U Keller; S Barandun; P Kistler; J S Ploem
Journal:  Exp Cell Res       Date:  1979-09       Impact factor: 3.905

2.  Effect of phagocytosis and Fc receptor occupancy on complement-dependent neutrophil chemotaxis.

Authors:  N E Kay; T F Bumol; S D Douglas
Journal:  J Lab Clin Med       Date:  1978-05

3.  Intrinsically stable IgG aggregates.

Authors:  D McCarthy; D H Goddard; B K Pell; E J Holborow
Journal:  J Immunol Methods       Date:  1981       Impact factor: 2.303

4.  Inhibition of neutrophil migration by sera from patients with rheumatoid arthritis.

Authors:  A S Kemp; P Roberts-Thomson; S H Neoh; S Brown
Journal:  Clin Exp Immunol       Date:  1979-06       Impact factor: 4.330

5.  Impaired polymorphonuclear leucocyte chemotaxis in rheumatoid arthritis.

Authors:  D H Goddard; A P Kirk; J R Kirwan; G D Johnson; E J Holborow
Journal:  Ann Rheum Dis       Date:  1984-04       Impact factor: 19.103

6.  Effects of human IgG on locomotion of human neutrophils related to IgG binding of a hydrophobic probe.

Authors:  P C Wilkinson
Journal:  Immunology       Date:  1980-10       Impact factor: 7.397

7.  Inhibition of human neutrophil migration by aggregated gammaglobulin.

Authors:  A Kemp; P Roberts-Thomson; S Brown
Journal:  Clin Exp Immunol       Date:  1979-05       Impact factor: 4.330

8.  Chemotaxis of polymorphonuclear leukocytes from patients with rheumatoid arthritis.

Authors:  A G Mowat; J Baum
Journal:  J Clin Invest       Date:  1971-12       Impact factor: 14.808

9.  Leukocyte locomotion and chemotaxis. New methods for evaluation, and demonstration of a cell-derived chemotactic factor.

Authors:  S H Zigmond; J G Hirsch
Journal:  J Exp Med       Date:  1973-02-01       Impact factor: 14.307
  9 in total
  3 in total

1.  Chemotaxis and chemiluminescence responses of synovial fluid polymorphonuclear leucocytes during acute reactive arthritis.

Authors:  M Leirisalo-Repo; A Lauhio; H Repo
Journal:  Ann Rheum Dis       Date:  1990-08       Impact factor: 19.103

2.  Heat-induced aggregated human IgG modifies the adherence of human polymorphonuclear cells to cultured endothelium.

Authors:  K A Brown; D McCarthy; M Bull; R C Chasty; D C Dumonde
Journal:  Clin Exp Immunol       Date:  1989-09       Impact factor: 4.330

3.  Impaired polymorphonuclear leucocyte chemotaxis in rheumatoid arthritis.

Authors:  D H Goddard; A P Kirk; J R Kirwan; G D Johnson; E J Holborow
Journal:  Ann Rheum Dis       Date:  1984-04       Impact factor: 19.103
  3 in total

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