Left ventricular function in patients with coronary heart disease in the presence or absence of angina pectoris during exercise radionuclide ventriculography.

This study compares left ventricular (LV) performance during exercise in patients with angiographically documented coronary artery disease (CAD) based on the presence or absence of angina pectoris during the index exercise tests. The patients were divided into 2 groups: Group I included 31 patients who had angina pectoris during the test and Group II included 43 who did not. Multivessel CAD was present in 21 patients (68%) in Group I and 26 patients (60%) in Group II (difference not significant [NS]). There were no significant differences between the 2 groups in age, sex, history of diabetes mellitus, history of myocardial infarction and in the exercise duration, work load, heart rate and systolic blood pressure. Exercise-induced ST-segment depression was present in 48% of the patients in Group I and in 40% in Group II (NS). The mean LV ejection fraction at rest was 52 +/- 12% in Group I and 50 +/- 17% in Group II (NS). There were significant differences in the 2 groups in the change from rest to exercise in ejection fraction (-4.5 +/- 7.6% in Group I vs 1 +/- 9.4% in Group II, p less than 0.01), end-systolic volume (29 +/- 38 ml in Group I vs 9 +/- 23 ml in Group II, p less than 0.005), the change in systolic blood pressure-to-end-systolic volume ratio (-0.1 +/- 0.5 mm Hg/ml in Group I vs 0.3 +/- 1.1 mm Hg/ml in Group II, p less than 0.05), and wall motion score (-0.4 +/- 0.6 in Group I vs 0.09 +/- 0.7 in Group II, p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

RCT Entities:   Population Interventions Outcomes