Literature DB >> 6710145

Metabolic mapping of the brain during rewarding self-stimulation.

L J Porrino, R U Esposito, T F Seeger, A M Crane, A Pert, L Sokoloff.   

Abstract

Local rates of cerebral glucose utilization were measured in rats by the quantitative 2-deoxy-D-[14C]glucose autoradiographic method during electrical stimulation of the ventral tegmental area. Rats trained in intracranial self-stimulation showed a pattern of changes in forebrain metabolic activity distinctly different from the pattern seen in rats stimulated by the experimenter. These findings provide information about the distribution of local cerebral activity specific to reinforced instrumental behavior.

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Year:  1984        PMID： 6710145     DOI： 10.1126/science.6710145

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

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2.  Learning-induced change in neural activity during acquisition and consolidation of a passive avoidance response in the rat.

Authors:  E Doyle; P M Nolan; C M Regan
Journal:  Neurochem Res       Date:  1990-05       Impact factor: 3.996

Review 3.  Self-stimulation: a rewarding decade.

Authors:  C H Bielajew; T Harris
Journal:  J Psychiatry Neurosci       Date:  1991-09       Impact factor: 6.186

4.  Medial forebrain bundle lesions fail to structurally and functionally disconnect the ventral tegmental area from many ipsilateral forebrain nuclei: implications for the neural substrate of brain stimulation reward.

Authors:  J M Simmons; R F Ackermann; C R Gallistel
Journal:  J Neurosci       Date:  1998-10-15       Impact factor: 6.167

5.  Effects of ethanol on cocaine self-administration in monkeys responding under a second-order schedule of reinforcement.

Authors:  William S John; Michael A Nader
Journal:  Drug Alcohol Depend       Date:  2016-11-10       Impact factor: 4.492

6.  Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats.

Authors:  R A Wise; P Newton; K Leeb; B Burnette; D Pocock; J B Justice
Journal:  Psychopharmacology (Berl)       Date:  1995-07       Impact factor: 4.530

7.  Cocaine's colocalized effects on synaptic serotonin and dopamine in ventral tegmentum in a reinforcement paradigm.

Authors:  P A Broderick
Journal:  Pharmacol Biochem Behav       Date:  1992-08       Impact factor: 3.533
  7 in total

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