Literature DB >> 6709825

Inhibition of DNA-ethidium bromide intercalation due to free radical attack upon DNA. I. Comparison of the effects of various radicals.

W A Prütz.   

Abstract

The fluorescent intercalation complex of ethidium bromide (ETB) with DNA was used as a probe to compare the effects of various radicals with respect to impairment of the DNA base-pair region. .OH radicals inhibit up to 0.7 dye intercalations per .OH at low salt concentration, and for various oxidizing species the effect decreases in the order .OH greater than Br.2- greater than N.3 much greater than (SCN).2-. DNA impairment by the .OH product of Met-Gly is comparable to that of N.3, but no effect was found due to the interaction between DNA and Lys-Tyr-Lys phenoxyl radicals. The reducing species e-aq, H., O.2-, and CO.2- hardly affect the DNA-ETB intercalation.

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Year:  1984        PMID： 6709825     DOI： 10.1007/bf01326731

Source DB:  PubMed          Journal:  Radiat Environ Biophys        ISSN： 0301-634X            Impact factor:   1.925


  8 in total

1.  Stacking interactions of ethidium bromide bound to a polyphosphate and phage DNA in situ.

Authors:  G Löber; J Koudelka; E Smékal E+SMEKAL
Journal:  Biophys Chem       Date:  1974-08       Impact factor: 2.352

2.  Native and denatured DNA, cross-linked and palindromic DNA and circular covalently-closed DNA analysed by a sensitive fluorometric procedure.

Authors:  A R Morgan; D E Pulleyblank
Journal:  Biochem Biophys Res Commun       Date:  1974-11-27       Impact factor: 3.575

3.  Phenol coupling initiated by one-electron oxidation of tyrosine units in peptides and histone.

Authors:  W A Prütz; J Butler; E J Land
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1983-08

4.  Reaction of azide radicals with amino acids and proteins.

Authors:  E J Land; W A Prütz
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1979-07

5.  Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation.

Authors:  H C Birnboim; J J Jevcak
Journal:  Cancer Res       Date:  1981-05       Impact factor: 12.701

6.  A fluorescent complex between ethidium bromide and nucleic acids. Physical-chemical characterization.

Authors:  J B LePecq; C Paoletti
Journal:  J Mol Biol       Date:  1967-07-14       Impact factor: 5.469

7.  Inhibition of DNA-ethidium bromide intercalation due to free radical attack upon DNA. II. Copper(II)-catalysed DNA damage by O.2-.

Authors:  W A Prütz
Journal:  Radiat Environ Biophys       Date:  1984       Impact factor: 1.925

8.  Influence of DNA binding on the formation and reactions of tryptophan and tyrosine radicals in peptides and proteins.

Authors:  J R Casas-Finet; J J Toulmé; R Santus; J Butler; E J Land; A J Swallow
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1984-02
  8 in total
  5 in total

1.  Inhibition of DNA-ethidium bromide intercalation due to free radical attack upon DNA. II. Copper(II)-catalysed DNA damage by O.2-.

Authors:  W A Prütz
Journal:  Radiat Environ Biophys       Date:  1984       Impact factor: 1.925

2.  Radiation-induced double-strand modification in calf thymus DNA in the presence of 1,2-dihydroxy-9,10-anthraquinone and its Cu(II) complex.

Authors:  S Das; A Saha; P C Mandal
Journal:  Environ Health Perspect       Date:  1997-12       Impact factor: 9.031

3.  Radioprotection of thymine and calf thymus DNA by an azo compound: mechanism of action followed by DPPH radical quenching & ROS depletion in WI 38 lung fibroblast cells.

Authors:  Durba Ganguly; Ramesh Chandra Santra; Swagata Mazumdar; Abhijit Saha; Parimal Karmakar; Saurabh Das
Journal:  Heliyon       Date:  2020-05-29

4.  In Situ Reactivity of Electrochemically Generated Nitro Radical Anion on Tinidazole and Its Monomeric and Dimeric CuII Complexes on Model Biological Targets with Relative Manifestation of Preventing Bacterial Biofilm Formation.

Authors:  Promita Nandy; Ramesh C Santra; Dibyajit Lahiri; Moupriya Nag; Saurabh Das
Journal:  ACS Omega       Date:  2022-03-01

5.  Conjugation of benzylvanillin and benzimidazole structure improves DNA binding with enhanced antileukemic properties.

Authors:  Zena A Al-Mudaris; Aman S A Majid; Dan Ji; Ban A Al-Mudarris; Shih-Hsun Chen; Po-Huang Liang; Hasnah Osman; Shah Kamal Khan Jamal Din; Amin M S Abdul Majid
Journal:  PLoS One       Date:  2013-11-15       Impact factor: 3.240
  5 in total

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