Literature DB >> 6708970

The motor end-plate fine structure and ultrastructural localization of acetylcholine receptors in amyotrophic lateral sclerosis.

M Tsujihata, R Hazama, T Yoshimura, A Satoh, M Mori, S Nagataki.   

Abstract

The motor end-plate fine structure and distribution of junctional acetylcholine receptors (AChRs) in patients with amyotrophic lateral sclerosis (ALS) were studied. Morphometric analysis was carried out in 74 end-plates (92 innervated and 47 denuded postsynaptic regions) from 10 patients with ALS. AChR was studied by means of peroxidase-labeled alpha-bungarotoxin binding in 45 end-plates (86 innervated and 36 denuded postsynaptic regions) from 6 patients with ALS. The postsynaptic regions were denuded of their nerve terminals in 33.8% (9.8% in controls). However, the postsynaptic folds in denuded regions were fairly well preserved, as were junctional AChRs. No highly simplified postsynaptic regions were observed. These results suggest that reinnervation of the skeletal muscle by nerve sprouting in ALS may occur in the previously denuded postsynaptic regions and the preserved postsynaptic regions including AChRs, the basement membrane, and Schwann cells may play an important role in this process.

Entities:  

Mesh:

Substances:

Year:  1984        PMID: 6708970     DOI: 10.1002/mus.880070310

Source DB:  PubMed          Journal:  Muscle Nerve        ISSN: 0148-639X            Impact factor:   3.217


  14 in total

1.  Acetylcholine receptors from human muscle as pharmacological targets for ALS therapy.

Authors:  Eleonora Palma; Jorge Mauricio Reyes-Ruiz; Diego Lopergolo; Cristina Roseti; Cristina Bertollini; Gabriele Ruffolo; Pierangelo Cifelli; Emanuela Onesti; Cristina Limatola; Ricardo Miledi; Maurizio Inghilleri
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-29       Impact factor: 11.205

2.  Circuit Dysfunction in SOD1-ALS Model First Detected in Sensory Feedback Prior to Motor Neuron Degeneration Is Alleviated by BMP Signaling.

Authors:  Aaron Held; Paxton Major; Asli Sahin; Robert A Reenan; Diane Lipscombe; Kristi A Wharton
Journal:  J Neurosci       Date:  2019-01-18       Impact factor: 6.167

Review 3.  Neuromuscular Junction Dysfunction in Amyotrophic Lateral Sclerosis.

Authors:  Sagar Verma; Shiffali Khurana; Abhishek Vats; Bandana Sahu; Nirmal Kumar Ganguly; Pradip Chakraborti; Mandaville Gourie-Devi; Vibha Taneja
Journal:  Mol Neurobiol       Date:  2022-01-08       Impact factor: 5.590

4.  A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress.

Authors:  Sebastian Thams; Emily Rhodes Lowry; Marie-Hélène Larraufie; Krista J Spiller; Hai Li; Damian J Williams; Phuong Hoang; Elise Jiang; Luis A Williams; Jackson Sandoe; Kevin Eggan; Ivo Lieberam; Kevin C Kanning; Brent R Stockwell; Christopher E Henderson; Hynek Wichterle
Journal:  Mol Ther       Date:  2018-10-19       Impact factor: 11.454

Review 5.  The BMP signaling pathway at the Drosophila neuromuscular junction and its links to neurodegenerative diseases.

Authors:  Vafa Bayat; Manish Jaiswal; Hugo J Bellen
Journal:  Curr Opin Neurobiol       Date:  2010-09-09       Impact factor: 6.627

6.  Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease.

Authors:  Qiao Ding; Kaamini Kesavan; Robert D Henderson; Pamela A McCombe; Rosalind L Jeffree; William D Phillips; Ernst J Wolvetang; Shyuan T Ngo; Peter G Noakes; Kah Meng Lee; Elyse Wimberger; Thomas Robertson; Melinder Gill; Dominique Power; Jeryn Chang; Atefeh T Fard; Jessica C Mar; Susan Heggie; Michael J Colditz; Massimo A Hilliard; Dominic C H Ng; Frederik J Steyn
Journal:  Acta Neuropathol Commun       Date:  2022-04-25       Impact factor: 7.578

7.  Endplate denervation correlates with Nogo-A muscle expression in amyotrophic lateral sclerosis patients.

Authors:  Gaëlle Bruneteau; Stéphanie Bauché; Jose Luis Gonzalez de Aguilar; Guy Brochier; Nathalie Mandjee; Marie-Laure Tanguy; Ghulam Hussain; Anthony Behin; Frédéric Khiami; Elhadi Sariali; Caroline Hell-Remy; François Salachas; Pierre-François Pradat; Lucette Lacomblez; Sophie Nicole; Bertrand Fontaine; Michel Fardeau; Jean-Philippe Loeffler; Vincent Meininger; Emmanuel Fournier; Jeanine Koenig; Daniel Hantaï
Journal:  Ann Clin Transl Neurol       Date:  2015-02-16       Impact factor: 4.511

8.  Characterization of early pathogenesis in the SOD1(G93A) mouse model of ALS: part II, results and discussion.

Authors:  Sharon Vinsant; Carol Mansfield; Ramon Jimenez-Moreno; Victoria Del Gaizo Moore; Masaaki Yoshikawa; Thomas G Hampton; David Prevette; James Caress; Ronald W Oppenheim; Carol Milligan
Journal:  Brain Behav       Date:  2013-06-11       Impact factor: 2.708

9.  Characterization of early pathogenesis in the SOD1(G93A) mouse model of ALS: part I, background and methods.

Authors:  Sharon Vinsant; Carol Mansfield; Ramon Jimenez-Moreno; Victoria Del Gaizo Moore; Masaaki Yoshikawa; Thomas G Hampton; David Prevette; James Caress; Ronald W Oppenheim; Carol Milligan
Journal:  Brain Behav       Date:  2013-06-11       Impact factor: 2.708

10.  Morphological analysis of neuromuscular junction development and degeneration in rodent lumbrical muscles.

Authors:  James N Sleigh; Robert W Burgess; Thomas H Gillingwater; M Zameel Cader
Journal:  J Neurosci Methods       Date:  2014-02-14       Impact factor: 2.390

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.