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Literature DB >> 6708949

A novel factor for DNA-dependent RNA polymerase II in rat liver nuclei.

Abstract

The author found, in rat liver nuclei, a novel factor which exhibited a strong inhibitory effect on RNA chain initiation by various classes of RNA polymerases (I, II and III) using an exogenous DNA template. The molecular weight of this factor was estimated to be 70 K daltons, and its activity was not affected by treatment with trypsin, RNase A, lipase C, alpha-amylase and heat. However, its activity was inactivated by a digestion of glycosidases. The molecule is shown to contain a considerable amount of sugars by physicochemical analysis. In addition, it is elucidated that the factor is not heparin which has a similar biological activity.

Entities: Chemical Gene Species

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Year: 1984 PMID： 6708949 DOI： 10.1007/bf00775354

Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316

13 in total

1. Transcription of DNA and chromatin with calf thymus RNA polymerase B in vitro.

Authors: H Cedar
Journal: J Mol Biol Date: 1975-06-25 Impact factor: 5.469

2. Inhibition of transcription in vitro by a non-histone protein isolated from Ehrlich ascites tumor chromatin.

Authors: N C Kostraba; T Y Wang
Journal: J Biol Chem Date: 1975-12-10 Impact factor: 5.157

3. The mechanism by which heparin stimulates transcription in isolated rat liver nuclei. Polyribonucleotide elongation rates and the number of transcribing RNA polymerase molecules present.

Authors: B E Coupar; C J Chesterton
Journal: Eur J Biochem Date: 1977-10-03

1. An increase of the regulating factor for chromatin-dependent RNA polymerase II reactions in the tightly-bound chromatin fraction by glucocorticoid injection.

Authors: Y Okai
Journal: Mol Biol Rep Date: 1985-04 Impact factor: 2.316

1 in total

A novel factor for DNA-dependent RNA polymerase II in rat liver nuclei.

1. Transcription of DNA and chromatin with calf thymus RNA polymerase B in vitro.

2. Inhibition of transcription in vitro by a non-histone protein isolated from Ehrlich ascites tumor chromatin.

3. The mechanism by which heparin stimulates transcription in isolated rat liver nuclei. Polyribonucleotide elongation rates and the number of transcribing RNA polymerase molecules present.

4. Some observations on a protein-mucopolysaccharide complex found in sea urchin embryos.

5. DNA dependent RNA polymerase from ehrlich ascites tumor cells. IV. A novel protein repressing RNA polymerase II.

6. Effect of protein-bound RNA associated with chick embryo chromatin on template specificity of the chromatin.

7. A proteoglycan form of heparin and its degradation to single-chain molecules.

8. Calcium effects on free and chromatin-bound RNA polymerase II reactions.

9. Multiple factors required for accurate initiation of transcription by purified RNA polymerase II.

10. Two species of RNA polymerase II released from rat liver chromatin.

1. An increase of the regulating factor for chromatin-dependent RNA polymerase II reactions in the tightly-bound chromatin fraction by glucocorticoid injection.