Literature DB >> 6708401

Red blood cell glutathione peroxidase activity in multiple sclerosis.

B Zachara, J Gromadzińska, J Czernicki, Z Maciejek, H Chmielewski.   

Abstract

Glutathione peroxidase (GSH-Px) activity of red blood cells of 23 multiple sclerosis (MS) patients (10 men and 13 women, aged 22-64 years) was examined and compared to the enzyme activity of 26 healthy persons (15 men and 11 women, aged 19-50 years). It was found that the mean GSH-Px activity was significantly higher (P less than 0.001) in red blood cells of MS patients (39.1 +/- 8.1 IU/g Hb) as compared to the group of healthy persons (25.9 +/- 5.2 IU/g Hb). There was no difference according to sexes in both the MS patients and the control group. The results are discussed based on the hypothesis that organic peroxides play a role in the etiology of multiple sclerosis.

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Year:  1984        PMID: 6708401     DOI: 10.1007/bf01731641

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN: 0023-2173


  33 in total

Review 1.  Multiple sclerosis: a new hypothesis.

Authors:  H S Mickel
Journal:  Perspect Biol Med       Date:  1975       Impact factor: 1.416

2.  Prostaglandins and kidney function. An experimental study in the rabbit.

Authors:  E Oliw
Journal:  Acta Physiol Scand Suppl       Date:  1979

3.  Comparison of electrophoresis on agar gel and agarose gel in the evaluation of gamma-globulin abnormalities in cerebrospinal fluid and serum in multiple sclerosis.

Authors:  H Link
Journal:  Clin Chim Acta       Date:  1973-07-27       Impact factor: 3.786

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Authors:  J Palo; J Wikström; E Kivalo
Journal:  Lancet       Date:  1973-10-13       Impact factor: 79.321

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Authors:  J Prineas
Journal:  Acta Neurol Scand       Date:  1968       Impact factor: 3.209

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Authors:  B Gerstl; L F Eng; M Tavaststjerna; J K Smith; S L Kruse
Journal:  J Neurochem       Date:  1970-05       Impact factor: 5.372

7.  Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.

Authors:  D E Paglia; W N Valentine
Journal:  J Lab Clin Med       Date:  1967-07

8.  Blood selenium and glutathione peroxidase activity in normal subjects and in surgical patients with and without cancer in New Zealand.

Authors:  M F Robinson; P J Godfrey; C D Thomson; H M Rea; A M van Rij
Journal:  Am J Clin Nutr       Date:  1979-07       Impact factor: 7.045

9.  Purification and properties of human erythrocyte glutathione peroxidase.

Authors:  Y C Awasthi; E Beutler; S K Srivastava
Journal:  J Biol Chem       Date:  1975-07-10       Impact factor: 5.157

10.  Leucocyte glutathione peroxidase activity and selenium level in multiple sclerosis.

Authors:  G E Jensen; G Gissel-Nielsen; J Clausen
Journal:  J Neurol Sci       Date:  1980-10       Impact factor: 3.181

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  3 in total

1.  Glutathione peroxidase activity, selenium, and lipid peroxide concentrations in blood from a healthy Polish population : I. Maternal and cord blood.

Authors:  B A Zachara; W Wąsowicz; J Gromadzińska; M Skłodowska; G Krasomski
Journal:  Biol Trace Elem Res       Date:  1986-09       Impact factor: 3.738

2.  Lipid peroxidation products and antioxidant proteins in plasma and cerebrospinal fluid from multiple sclerosis patients.

Authors:  M I Hunter; B C Nlemadim; D L Davidson
Journal:  Neurochem Res       Date:  1985-12       Impact factor: 3.996

Review 3.  Immunology and oxidative stress in multiple sclerosis: clinical and basic approach.

Authors:  Genaro G Ortiz; Fermín P Pacheco-Moisés; Oscar K Bitzer-Quintero; Ana C Ramírez-Anguiano; Luis J Flores-Alvarado; Viridiana Ramírez-Ramírez; Miguel A Macias-Islas; Erandis D Torres-Sánchez
Journal:  Clin Dev Immunol       Date:  2013-09-24
  3 in total

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