Literature DB >> 6707526

Utilization of different fatty acyl-CoA thioesters by serine palmitoyltransferase from rat brain.

A H Merrill, R D Williams.   

Abstract

Serine palmitoyltransferase (EC 2.3.1.50) catalyzes the first unique reaction of sphingolipid biosynthesis. Activities were determined with different fatty acyl-CoA substrates to describe the range of long-chain bases that could be made by rat brain microsomes. The activities were greatest with palmitoyl-CoA and palmitelaidoyl-CoA, followed by fully saturated homologs differing from these by only one carbon atom, and diminished considerably as the alkyl-chain length increased or decreased, or with the presence of a cis-double bond. These characteristics explain the predominance of long-chain bases with 18 carbon atoms in brain sphingolipids, and account for the minor variants such as the C17- and C20-long chain bases.

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Year:  1984        PMID： 6707526

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


  11 in total

1.  An improved method to determine serine palmitoyltransferase activity.

Authors:  Markus F Rütti; Stéphane Richard; Anke Penno; Arnold von Eckardstein; Thorsten Hornemann
Journal:  J Lipid Res       Date:  2009-01-29       Impact factor: 5.922

2.  Ethanol-induced alterations in fatty acid-related lipids in serum and tissues in mice.

Authors:  Zhenwen Zhao; Menggang Yu; David Crabb; Yan Xu; Suthat Liangpunsakul
Journal:  Alcohol Clin Exp Res       Date:  2010-11-08       Impact factor: 3.455

3.  Viral serine palmitoyltransferase induces metabolic switch in sphingolipid biosynthesis and is required for infection of a marine alga.

Authors:  Carmit Ziv; Sergey Malitsky; Alaa Othman; Shifra Ben-Dor; Yu Wei; Shuning Zheng; Asaph Aharoni; Thorsten Hornemann; Assaf Vardi
Journal:  Proc Natl Acad Sci U S A       Date:  2016-03-16       Impact factor: 11.205

4.  Semi-rational approach to expand the Acyl-CoA Chain length tolerance of Sphingomonas paucimobilis serine palmitoyltransferase.

Authors:  Hyunjun Choe; Minsun Cha; Jon D Stewart
Journal:  Enzyme Microb Technol       Date:  2020-01-21       Impact factor: 3.493

5.  Sphingolipid Long-Chain Base Synthesis in Plants (Characterization of Serine Palmitoyltransferase Activity in Squash Fruit Microsomes).

Authors:  D. V. Lynch; S. R. Fairfield
Journal:  Plant Physiol       Date:  1993-12       Impact factor: 8.340

6.  Differences in the long chain (sphingoid) base composition of sphingomyelin from rats bearing Morris hepatoma 7777.

Authors:  A H Merrill; E Wang; P W Wertz
Journal:  Lipids       Date:  1986-08       Impact factor: 1.880

7.  Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties.

Authors:  Sarah Brice Russo; Rotem Tidhar; Anthony H Futerman; L Ashley Cowart
Journal:  J Biol Chem       Date:  2013-03-25       Impact factor: 5.157

8.  The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases.

Authors:  Thorsten Hornemann; Anke Penno; Markus F Rütti; Daniela Ernst; Fatma Kivrak-Pfiffner; Lucia Rohrer; Arnold von Eckardstein
Journal:  J Biol Chem       Date:  2009-08-01       Impact factor: 5.157

9.  Importance of the sphingoid base length for the membrane properties of ceramides.

Authors:  Terhi Maula; Ibai Artetxe; Pia-Maria Grandell; J Peter Slotte
Journal:  Biophys J       Date:  2012-11-07       Impact factor: 4.033

Review 10.  Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols.

Authors:  Sarah T Pruett; Anatoliy Bushnev; Kerri Hagedorn; Madhura Adiga; Christopher A Haynes; M Cameron Sullards; Dennis C Liotta; Alfred H Merrill
Journal:  J Lipid Res       Date:  2008-05-21       Impact factor: 5.922
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