Literature DB >> 670711

Kinetics of immunoglobulin production by cultured human peripheral blood lymphocytes.

S M McLachlan, B R Smith, R Hall.   

Abstract

A study of immunoglobulin synthesis by human peripheral blood lymphocytes cultured in Marbrook flasks is described. Maximal amounts of immunoglobulin were produced by 3 weeks and most of this was synthesised between 6 and 21 days. In the region of 90% of the immunoglobulin was secreted into the medium. Pokeweed mitogen (PWM) stimulated cultures produced about 10 times as much immunoglobulin as cells cultured in medium only. After 21 days stimulated cultures produced about 150 microgram of IgG, 125 microgram of IgM and 50 microgram of IgA per 10(7) cells.

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Year:  1978        PMID： 670711     DOI： 10.1016/0022-1759(78)90147-3

Source DB:  PubMed          Journal:  J Immunol Methods        ISSN： 0022-1759            Impact factor:   2.303


  9 in total

1.  Functional analysis of T and B cells from blood and thyroid tissue in Hashimoto's disease.

Authors:  S M McLachlan; G Proud; C A Pegg; F Clark; B Rees Smith
Journal:  Clin Exp Immunol       Date:  1985-03       Impact factor: 4.330

2.  Immunoregulatory T-cell dysfunction in polyclonal gammopathy.

Authors:  R A Robinson; N L Abdou; N I Abdou
Journal:  J Clin Immunol       Date:  1981-01       Impact factor: 8.317

3.  Enrichment and depletion of thyroglobulin autoantibody synthesizing lymphocytes.

Authors:  S M McLachlan; A Dickinson; P Baylis; S Proctor; B Rees Smith
Journal:  Clin Exp Immunol       Date:  1983-08       Impact factor: 4.330

4.  Thyroid autoantibody synthesis by cultures of thyroid and peripheral blood lymphocytes. I. Lymphocyte markers and response to pokeweed mitogen.

Authors:  S M McLachlan; A M Dickinson; A Malcolm; J R Farndon; E Young; S J Proctor; B R Smith
Journal:  Clin Exp Immunol       Date:  1983-04       Impact factor: 4.330

5.  Mitogen-stimulated immunoglobulin production by chronic lymphocytic leukaemic lymphocytes.

Authors:  A P Johnstone; J C Jensenius; R E Millard; L Hudson
Journal:  Clin Exp Immunol       Date:  1982-03       Impact factor: 4.330

6.  Thyroid autoantibody synthesis by lymphocytes from different lymphoid organs: fractionation of B cells on density gradients.

Authors:  M C Atherton; S M McLachlan; C A Pegg; A Dickinson; P Baylis; E T Young; S J Proctor; B Rees Smith
Journal:  Immunology       Date:  1985-06       Impact factor: 7.397

7.  Thyroglobulin and microsomal autoantibody production by cultures of Hashimoto peripheral blood lymphocytes.

Authors:  A McGregor; S McLachlan; F Clark; B R Smith; R Hall
Journal:  Immunology       Date:  1979-01       Impact factor: 7.397

8.  Thyroid autoantibody synthesis by cultures of thyroid and peripheral blood lymphocytes. II. Effect of thyroglobulin on thyroglobulin antibody synthesis.

Authors:  S M McLachlan; J Fawcett; M C Atherton; P Thompson; P Baylis; B R Smith
Journal:  Clin Exp Immunol       Date:  1983-06       Impact factor: 4.330

9.  Antibody-mediated killing of suppressor T lymphocytes as a possible cause of macroglobulinemia in the tropical splenomegaly syndrome.

Authors:  W F Piessens; S L Hoffman; A A Wadee; P W Piessens; S Ratiwayanto; L Kurniawan; J R Campbell; H A Marwoto; L L Laughlin
Journal:  J Clin Invest       Date:  1985-06       Impact factor: 14.808
  9 in total

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