Literature DB >> 6705829

Endothelial cell-dependent relaxation and contraction induced by histamine in the isolated guinea-pig pulmonary artery.

H Satoh, J Inui.   

Abstract

Histamine (10(-8)-10(-6) M) relaxed in a concentration-dependent manner the guinea-pig pulmonary artery which had been contracted by noradrenaline (5 X 10(-7) M). After the removal of endothelial cells (ETCs) histamine at the same concentrations did not cause relaxation but induced additional contraction. Both responses to histamine were antagonized by chlorpheniramine (3 X 10(-7) M). These results suggest that in the pulmonary artery histamine simultaneously stimulates H1-receptors located on both ETCs and smooth muscle cells. This results in two opposite effects, relaxation mediated by ETCs, and contraction.

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Year:  1984        PMID： 6705829     DOI： 10.1016/0014-2999(84)90468-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  14 in total

1.  Inhibition of endothelium-dependent smooth muscle relaxation by calmodulin antagonists.

Authors:  G Weinheimer; H Osswald
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-04       Impact factor: 3.000

2.  Influence of the epithelium on responsiveness of guinea-pig isolated trachea to contractile and relaxant agonists.

Authors:  R G Goldie; J M Papadimitriou; J W Paterson; P J Rigby; H M Self; D Spina
Journal:  Br J Pharmacol       Date:  1986-01       Impact factor: 8.739

3.  Endothelium-dependent relaxing effect of histamine on the isolated guinea-pig main pulmonary artery strips.

Authors:  N Abacioğlu; Z S Ercan; L Kanzik; H Zengil; T Demiryürek; R K Türker
Journal:  Agents Actions       Date:  1987-10

4.  Effect of histamine on human bronchial arteries in vitro.

Authors:  S F Liu; M Yacoub; P J Barnes
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-07       Impact factor: 3.000

Review 5.  The role of endothelium in the control of vascular tone.

Authors:  R Busse; G Trogisch; E Bassenge
Journal:  Basic Res Cardiol       Date:  1985 Sep-Oct       Impact factor: 17.165

6.  Molecular characterization of specific H1-receptor agonists histaprodifen and its Nalpha-substituted analogues on bovine aortic H1-receptors.

Authors:  Marija Carman-Krzan; Aljosa Bavec; Matjaz Zorko; Walter Schunack
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-03-25       Impact factor: 3.000

7.  Identification of arginine as a precursor of endothelium-derived relaxing factor.

Authors:  I Sakuma; D J Stuehr; S S Gross; C Nathan; R Levi
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

8.  Alterations with age of the response to vasodilator agents in isolated mesenteric arteries of the beagle.

Authors:  I Shimizu; N Toda
Journal:  Br J Pharmacol       Date:  1986-12       Impact factor: 8.739

9.  Pertussis toxin and N-ethylmaleimide inhibit histamine- but not calcium ionophore-induced endothelium-dependent relaxation.

Authors:  G Weinheimer; H Osswald
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989 Jan-Feb       Impact factor: 3.000

10.  Characterization of the histamine receptors in the guinea-pig lung: evidence for relaxant histamine H3 receptors in the trachea.

Authors:  L O Cardell; L Edvinsson
Journal:  Br J Pharmacol       Date:  1994-02       Impact factor: 8.739
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