Literature DB >> 6705234

Simultaneous determination of catecholamines and metanephrines in urine by HPLC with fluorometric detection.

N G Abeling, A H van Gennip, H Overmars, P A Voûte.   

Abstract

A method is described for quantitative analysis of urinary free and conjugated catecholamines and metanephrines. The compounds are isolated from the urine by cation exchange on Amberlite CG 50. Separation is performed by ion-pair reversed-phase high-performance liquid chromatography. For detection of the amines their native fluorescence emitted at 313 nm on excitation at 285 nm was monitored. There was good separation of the compounds of interest, while interference by exogenous compounds other than the catecholamines or metanephrines was minimal. The method is rapid and precise, and it has a broad linear working range for all six DOPA metabolites, making it suitable for clinical analysis. Reference values for children of 0-16 years were established. Examples are shown of excretion patterns of DOPA metabolites from patients with different types of neurogenic tumour.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6705234     DOI： 10.1016/0009-8981(84)90181-5

Source DB:  PubMed          Journal:  Clin Chim Acta        ISSN： 0009-8981            Impact factor:   3.786


  8 in total

1.  Aromatic L-amino acid decarboxylase deficiency: a new case with a mild clinical presentation and unexpected laboratory findings.

Authors:  N G Abeling; A H van Gennip; P G Barth; A van Cruchten; M Westra; F A Wijburg
Journal:  J Inherit Metab Dis       Date:  1998-06       Impact factor: 4.982

Review 2.  Realising the Potential of Urine and Saliva as Diagnostic Tools in Sport and Exercise Medicine.

Authors:  Angus Lindsay; Joseph T Costello
Journal:  Sports Med       Date:  2017-01       Impact factor: 11.136

3.  Biogenic amine metabolite patterns in the urine of monoamine oxidase A-deficient patients. A possible tool for diagnosis.

Authors:  N G Abeling; A H van Gennip; H Overmars; B A van Oost; H G Brunner
Journal:  J Inherit Metab Dis       Date:  1994       Impact factor: 4.982

4.  Tyrosine hydroxylase deficiency unresponsive to L-dopa treatment with unusual clinical and biochemical presentation.

Authors:  P DE Lonlay; M C Nassogne; A H van Gennip; A C van Cruchten; T Billatte de Villemeur; M Cretz; C Stoll; J M Launay; G C Steenberger-Spante; L P van den Heuvel; R A Wevers; J M Saudubray; N G Abeling
Journal:  J Inherit Metab Dis       Date:  2000-12       Impact factor: 4.982

5.  Advances in biochemical screening for phaeochromocytoma using biogenic amines.

Authors:  Malcolm J Whiting; Matthew P Doogue
Journal:  Clin Biochem Rev       Date:  2009-02

6.  Specific genetic deficiencies of the A and B isoenzymes of monoamine oxidase are characterized by distinct neurochemical and clinical phenotypes.

Authors:  J W Lenders; G Eisenhofer; N G Abeling; W Berger; D L Murphy; C H Konings; L M Wagemakers; I J Kopin; F Karoum; A H van Gennip; H G Brunner
Journal:  J Clin Invest       Date:  1996-02-15       Impact factor: 14.808

7.  X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism.

Authors:  H G Brunner; M R Nelen; P van Zandvoort; N G Abeling; A H van Gennip; E C Wolters; M A Kuiper; H H Ropers; B A van Oost
Journal:  Am J Hum Genet       Date:  1993-06       Impact factor: 11.025

8.  Refractory Stage M Ganglioneuroblastoma With Bone Metastases and a Favorable, Chronic Course of Disease: Description of a Patient Cohort.

Authors:  Michelle L Tas; Jan J Molenaar; Annemarie M L Peek; Maarten H Lequin; Rob M Verdijk; Ronald R de Krijger; Godelieve A M Tytgat; Max M van Noesel
Journal:  J Pediatr Hematol Oncol       Date:  2022-01-01       Impact factor: 1.289
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.